BACKGROUND The accurate identification of patients who have the potential to further deteriorate after cardiac surgery is difficult. Elevated serum lactate level after cardiac surgery is an indicator of systemic hypoperfusion and tissue hypoxia. The aim of this study was to investigate the effect of increased serum lactate on outcome after on-pump coronary artery bypass grafting. METHODS Seru...

Microbial conversion of renewable raw materials to useful products is an important objective in industrial biotechnology. Pichia stipitis, a yeast that naturally ferments xylose, was genetically engineered for l-(+)-lactate production. We constructed a P. stipitis strain that expressed the l-lactate dehydrogenase (LDH) from Lactobacillus helveticus under the control of the P. stipitis fermentat...

BACKGROUND Brain magnetic resonance spectroscopy (MRS) has been reported to be a valuable noninvasive tool in the diagnosis of some rare diseases. In this study, our aim was to assess lactate peak on single-voxel proton MRS in children with syndromic mitochondrial diseases (MDs). METHODS From March 2004 to November 2010, 14 patients who were diagnosed with syndromic MDs underwent single-voxel...

the aim of this study was to determine the effects of sodium bicarbonate supplementation on blood lactate level and anaerobic power of futsal players. 24 futsal players (mean age of 15.88±1.59 years, weight 62.02±12.76 kg, height 173.21±8.23 cm, bmi 20.51±3.33 kg/m2) were selected and randomly divided into two groups (experimental, n=12) and (control, n=12). the protocol consisted of a five-min...

Serum cortisol levels rise in response to stress of critical illness but the optimum range of serum cortisol in such settings is not clearly defined. An association of high lactate levels with mortality has been found in adult patients with septic shock. However there is controversial literature regarding the same in children. The aim of this study was to determine the serum cortisol level and ...

OBJECTIVE Altered mental status is a common cause of intensive care unit admission in children. Differentiating structural causes of altered mental status from metabolic etiologies is of utmost importance in diagnostic approach and management of the patients. Among many biomarkers proposed to help stratifying patients with altered mental status, spinal fluid lactate dehydrogenase appears to be ...

OBJECTIVE To correlate lactate clearance with Pediatric Intensive Care Unit (PICU) mortality. METHODS 45 (mean age 40.15 mo, 60% males) consecutive admissions in the PICU were enrolled between May 2012 to June 2013. Lactate clearance (Lactate level at admission - level 6 hr later x 100 / lactate level at admission) in first 6 hours of hospitalization was correlated to in-hospital mortality an...

This work reveals that, at pH 5-9, a lactate level of up to 30 g l(-1) retarded hydrolysis rates in polysaccharide-rich potato samples. Lactate substantially limited carbohydrate hydrolysis and enhanced the hydrolysis of proteins. Statistical analysis identified the significance of numerous process factors in substrate hydrolysis. At fixed pH, dissociated lactate affected hydrolysis rates more ...