Lipopolysaccharide (LPS), if released from the outer membrane of Gram-negative bacteria during blood stream infections, is causative for sepsis and septic shock syndrome, and thus is denominated endotoxin. Septic shock is characterized by an massive activation of human immune cells by LPS to produce proinflammatory cytokines leading to an overbording systemic response of the immune system and c...

Kim, JS; +Im, H-J +Department of Biochemistry, Orthopedic Surgery, Internal Medicine Rush University Medical Center, Chicago, IL60612 +Hee-Jeong [email protected] INTRODUCTION To date, research has shown that progressive breakdown of the extracellular matrix (ECM) is closely associated with disc degeneration. Therefore, biological treatments capable of promoting ECM repair and regeneration have b...

BACKGROUND Several short antimicrobial peptides that are rich in tryptophan and arginine residues were designed with a series of simple modifications such as end capping and cyclization. The two sets of hexapeptides are based on the Trp- and Arg-rich primary sequences from the "antimicrobial centre" of bovine lactoferricin as well as an antimicrobial sequence obtained through the screening of a...

α s2-casein f(183-207) and lactoferricin [lactoferrin f(17-41)] are two potent 3 antibacterial peptides derived from bovine milk proteins. The aim of this work was to 4 evaluate if the antimicrobial activity of natural compounds employed in food 5 preservation such as nisin could be enhanced by combination with the aforementioned 6 milk peptides. Combinations with lactoferrin were also performe...

Studies were undertaken to determine whether bovine lactoferrin (bLF) and related compounds, shown to prevent carcinogenesis in the colon and other organs in rats, have any toxic effects in long-term feeding studies. In experiment I, male F344/DuCrj rats received a basal diet containing 0.2% bLF for 40 weeks. No adverse findings were noted, furthermore, serum triglyceride level was significantl...