BACKGROUND DPP-4 inhibitors reportedly exert effects on both alpha and beta cells, and promote the proliferation and survival of beta cells. We investigated the effects of anagliptin on structurally-impaired islets of Langerhans in streptozotocin (STZ)-treated mice, fed either a normal or a high-fat diet. Pdx-1 expression in the pancreas and serum insulin/glucagon concentrations were also exami...

Context: Statins are administered to decrease atherosclerosis in patients with coronary heart disease. These drugs enhance the risk of diabetes by affecting islets insulin secretion. Objectives: Therefore, this systematic review investigates effect statins on secretion Langerhans related original studies. Methods: A preliminary search was performed PubMed, Scopus, Web Science, and ProQuest data...

Background Islets of Langerhans transplantation is a promising alternative for glycemic control in patients with type 1 diabetes. The graft site is a factor that has large impact on the functioning of this transplant, and the stomach appears to be a promising location. Our objective is to describe a new experimental model for the grafting of Islets of Langerhans in rat stomachs. Methodology I...

It has been recently proposed that exposure to polychlorinated biphenyls (PCBs) is a risk factor to type 2 diabetes mellitus (DM2). We investigated this hypothesis using long-term in vivo PCB126 exposure to rats addressing metabolic, cellular and proteomic parameters. Male Wistar rats were exposed to PCB126 (0.1, 1 or 10 μg/kg of body weight/day; for 15 days) or vehicle by intranasal instillati...

The present study was conducted to determine the antidiabetic effect of Momordica charantia on pancreatic islets Langerhans in streptozotocin-induced diabetic male Wistar rats relation distribution insulin immuno-positive beta cells. fed at 2 %, 5 % and 10 standard diet for 12 w. After sacrifice, tissues were obtained histopathological immunohistochemical observations. In addition, monitoring f...

The vascular network supporting the islets of Langerhans represents a highly specialised system arterioles, capillaries and venules. Several features islet vasculature (density fenestration capillaries) ensure rapid exchange nutrients hormones, which is central to islets' capacity control systemic metabolism via reciprocal changes insulin glucagon secretion. Here we discuss how in blood flow ma...

In previous studies we have shown that sulfatide (galactosylceramide-3-O-sulfate), in various species, is present in the insulin-producing cells in pancreatic islets of Langerhans. In this study the synthesis of sulfatide in the islets has been investigated by pulse chase labeling at varying glucose levels and in the presence or absence of the glycosphingolipid synthesis inhibitory agents, Bref...