Journal:
:international journal of hematology-oncology and stem cell research
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fereshteh maryami biotechnology research center, department of molecular medicine, pasteur institute of iran, tehran, iran
azita azarkeivan pediatric hematology oncology, transfusion research center, high institute for research and education in transfusion medicine, department of thalassemia clinic, tehran, iran
mohammad sadegh fallah kawsar human genetics research center, tehran, iran
sirous zeinali iranian molecular medicine network, biotechnology research center, pasteur institute of iran, pasteur st, tehran, iran
kawsar human genetics research center, tehran, iran
background: thalassemia syndromes are the most prevalent single gene disorders in iran. this study aimed to evaluate the effect of different types of beta-globin gene mutations, co-inheritance of alpha-globin gene mutations and/or xmn1 snp on disease phenotype in a large cohort of iranian patients. subjects and methods: in total, 433 patients were clinically classified into β-thalassemia major ...