1 Laboratório de Ecologia e Zoologia de Invertebrados, Instituto de Ciências Biológicas, Universidade Federal do Pará, Rua Augusto Corrêa, No. 1, Campus Básico, Guamá 66075-110 Belém, PA, Brazil 2 Laboratory of Apiculture and Social Insects (LASI), School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK 3Section of Ecology, Behavior, and Evolution, Division of Biological Sci...

Individuals with cystic fibrosis (CF) are commonly colonized with Pseudomonas aeruginosa. The chronic infections caused by P. aeruginosa are punctuated by acute exacerbations of the lung disease, which lead to significant morbidity and mortality. As regulators of virulence determinants, P. aeruginosa quorum-sensing systems may be active in the chronic lung infections associated with CF. We have...

There is an urgent need for novel strategies to fight drug resistance and multi-drug resistance. As an alternative to the classic antibiotic therapy, attenuation of the bacteria virulence affecting their Quorum sensing (QS) system is a promising approach. Quorum sensing (QS) is a genetic regulation system that allows bacteria to communicate with each other and coordinate group behaviors. A new ...

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main source(s): Danderyds Hospital Background Atrial fibrillation (AF) is associated with atrial disease expressing left (LA) structural remodeling increased fibrosis and stiffness. Transthoracic echocardiography (TTE) the first imaging modality choice for evaluation LA volume index (LAVI) functio...

Pseudomonas aeruginosa is an important pathogen that frequently associated with nosocomial infections. The goal of this work was to determine the relationship between quorum sensing system (QS) and production virulence factors in P. aeruginosa. A number 100 isolates were collected from various clinical sources different Mansoura university hospitals period April 2018 till 2019. PCR screening QS...

We report that 2 microg of azithromycin/ml inhibits the quorum-sensing circuitry of Pseudomonas aeruginosa strain PAO1. Addition of synthetic autoinducers partially restored the expression of the trancriptional activator-encoding genes lasR and rhlR but not that of the autoinducer synthase-encoding gene lasI. We propose that azithromycin interferes with the synthesis of autoinducers, by an unkn...

Abstract Background Left atrial stiffness index (LASI) derived from speckle-tracking echocardiography (STE) is a marker of pressure transfer to the pulmonary circulation and predictor symptoms in patients with heart failure (HF). However, role right (RASI) setting left-sided HF incompletely understood. Purpose We sought evaluate left, combined bi-atrial (BASI) cohort dilated cardiomyopathy (DCM...