The study was made with the help of a chemitrode placed in various areas of the hypothalamus by the stereotaxic technique, for electrical and chemical stimulation (noradrenaline or isoprenaline) before and after microinjection of respective blockers (phenoxybenzamine or practalol). The results indicated the presence of both alpha and beta-adrenoreceptors in the anterior and dorsomedial hypothal...

It is well known that lesions of the lateral hypothalamus (LH) produce aphagia. Several previous studies have reported that lateral hypothalamus damage produces food aversion in addition to aphagia. However, damage to other regions near the LH also produce aphagia and enhanced aversion. The purpose of this study was to resolve where the site or sites for aversion-inducing lesions is/are located...

Bilateral destructions of a well localised area in lateral hypothalamus led to complete cessation of eating, while lesions involving ventromedial nuclei or the region between these and lateral area produced hyperphagia and obesity. The lateral region (hunger mechanism) was designated 'feeding center' and the medial (inhibitory control) 'satiety center.' [The SCI indicates that this paper has be...

In this outline of the neural control of food intake, no attempt has been made to provide a comprehensive survey of the literature since there are several symposia and reviews available which summarize the extensive work in this field (Grossman, 1975; Novin et al. 1976; Silverstone, 1976; Morgane & Panksepp, 1980; Hoebel & Novin, 1982). Instead some current concepts of the neural control of foo...

The cytokine IL-1 mediates diverse forms of neurodegeneration, but its mechanism of action is unknown. We have demonstrated previously that exogenous and endogenous IL-1 acts specifically in the rat striatum to dramatically enhance ischemic and excitotoxic brain damage and cause extensive cortical injury. Here we tested the hypothesis that this distant effect of IL-1 is mediated through polysyn...