Evidence suggests that lean body mass (LBM) may be useful to normalize chemotherapy doses. Data from one prospective and one retrospective study were used to determine if the highest doses of oxaliplatin/kg LBM within FOLFOX regimens would be associated with dose-limiting toxicity (DLT) in colon cancer patients. Toxicity over four cycles was graded according to NCI Common Toxicity Criteria V2 o...

Lattice Boltzmann Method (LBM) is a novel numerical method for flows simulations. Compared with classic methods of Finite Difference Method, Finite Volume Method and Finite Element Method, LBM has numerous advantages, including inherent parallelization and simplicity of boundary condition treatment. The LBM usually has a constraint of incompressible fluid (Mach number less than 0.4). A variant ...

OBJECTIVE To investigate the long-term effects of nasal continuous positive airway pressure (CPAP) ventilation in patients with obstructive sleep apnea syndrome (OSAS) on body composition (BC) and IGF1. DESIGN Observational study. SUBJECTS Seventy-eight (11 females and 67 males) OSAS patients who were compliant with CPAP (age 51+/-1.1 years) participated in the study. We assessed body mass ...

BACKGROUND To determine the association of the A55T and K153R polymorphisms of the Myostatin gene with obesity, abdominal obesity and lean body mass (LBM) in Asian Indians in north India. MATERIALS AND METHODS A total of 335 subjects (238 men and 97 women) were assessed for anthropometry, % body fat (BF), LBM and biochemical parameters. Associations of Myostatin gene polymorphisms were evalua...

The present study investigated potential sex-related differences in the metabolic response to carbohydrate (CHO) ingestion during exercise. Moderately endurance-trained men and women (n = 8 for each sex) performed 2 h of cycling at approximately 67% Vo(2 max) with water (WAT) or CHO ingestion (1.5 g of glucose/min). Substrate oxidation and kinetics were quantified during exercise using indirect...

We have examined the responses of energy and protein metabolism to nutrient intake in nine patients with lung carcinoma, of whom none were cachexic and only one had distant metastases, compared with nine control patients for elective aneurysm surgery, who were comparable in terms of age, body mass index, and smoking habits. Whole-body protein turnover and leucine oxidation were assessed by prim...

Although catastrophic weight loss is no longer common in HIV-infected men, we hypothesized that a more gradual process of cachexia [loss of lean body mass (LBM) without severe weight loss, often accompanied by elevated resting energy expenditure (REE)] is still common and is driven by excessive production of the catabolic cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta ...

Lean body mass (LBM) and muscle mass remain difficult to quantify in large epidemiological studies due to the unavailability of inexpensive methods. We therefore developed anthropometric prediction equations to estimate the LBM and appendicular lean soft tissue (ALST) using dual-energy X-ray absorptiometry (DXA) as a reference method. Healthy volunteers (n = 2,220; 36% women; age 18-79 yr), rep...

The particle level set method (PLSM) and the lattice Boltzmann method (LBM) have been two major physics-based liquid simulation techniques used in computer graphics to generate splendid and dynamic visual effects. PLSM suffers from a high computational cost which arises from the global pressure correction step whereas LBM requires a large amount of memory to store distribution functions. In thi...

Abstract. In the present work the application of hierarchical grid refinement for the Lattice-Boltzmann Method (LBM) to simulate turbulent flows has been investigated. A transformation and interpolation scheme has been developed based on a volumetric approach, independent of a specific collision model and therefore, generally applicable to all variants of the LBM. Besides a short review of the ...