OBJECTIVE To explore trial participants' responses to receiving a summary of the results of a trial in pregnancy. DESIGN Qualitative study with semistructured interviews. PARTICIPANTS 20 women who had when pregnant participated in the ORACLE trial of antibiotics for preterm labour and preterm rupture of the membranes and requested a copy of the trial results. RESULTS Less than a fifth of ...

Hypertrophic cardiomyopathy (HCM) can be classified into at least four major anatomic subsets based upon the septal contour, and the location and extent of hypertrophy: reverse curvature-, sigmoidal-, apical-, and neutral contour-HCM. Here, we sought to identify genetic determinants for sigmoidal-HCM and hypothesized that Z-disc-HCM may be associated preferentially with a sigmoidal phenotype. U...

Myotonic dystrophy type I (DM1) exhibits distinctive disease specific phenotypes and the accelerated onset of a spectrum of age-associated pathologies. In DM1, dominant effects of expanded CUG repeats result in part from the inactivation of the muscleblind-like (MBNL) proteins. To test the role of MBNL3, we deleted Mbnl3 exon 2 (Mbnl3(ΔE2)) in mice and examined the onset of age-associated disea...

Abstract Background The lack of therapies for HFpEF patients is a major unmet need, thus identifying cardiac specific pathways in priority. Purpose Identify molecular features protein and phosphoprotein murine model Methods Studies followed the principles laboratory animal care (NIH Pub no. 85–23 revised 1985). (N=4) was induced by NaCl drinking water, unilateral nephrectomy, chronic aldosteron...

OBJECTIVE A variety of postmarketing surveillance strategies to monitor the safety of medical devices have been supported by the U.S. Food and Drug Administration, but there are few systems to automate surveillance. Our objective was to develop a system to perform real-time monitoring of safety data using a variety of process control techniques. DESIGN The Web-based Data Extraction and Longit...

This paper is a chronological story of the design, construction, and operation of the ORACLE over its ten year life cycle. The authors participated in all three stages of ORACLE's life cycle, and the material presented was extracted from personal files of the authors and annual reports of the Oak Ridge National Laboratory. This overview and description of the ORACLE reveals the nature of a firs...

The role of the off-diagonal density matrix elements of the entangled pair is investigated in quantum teleportation of a qbit. The dependence between them and the off-diagonal elements of the teleported density matrix is shown to be linear. In this way the ideal quantum teleportation is related to an entirely classical communication protocol: the one-time pad cypher. The latter can be regarded ...

OBJECTIVES The aim of this study was to compare the pharmacokinetics of the four limus-eluting stents used in Japanese patients. BACKGROUND There are presently no reports comparing human pharmacokinetics among drug-eluting stents (DESs). METHODS We retrospectively analyzed data from pharmacokinetic studies of patients implanted with an 18-mm DES: Cypher stent (sirolimus, n = 10), Endeavor s...

The Drosophila Alp/Enigma family protein Zasp52 localizes to myotendinous junctions and Z-discs. It is required for terminal muscle differentiation and muscle attachment. Its vertebrate ortholog ZASP/Cypher also localizes to Z-discs, interacts with α-actinin through its PDZ domain, and is involved in Z-disc maintenance. Human mutations in ZASP cause myopathies and cardiomyopathies. Here we show...