Abstract Background To assess the effects of proprotein convertase subtilisin/kexin type 9 inhibitor (evolocumab) on lipoprotein particles subfractions with Nuclear Magnetic Resonance spectroscopy in patients acute coronary syndromes. Methods A total 99 consecutive ACS were enrolled and assigned to either experimental group (n = 54) or control 45). The combination therapy PCSK9 (Repatha®, 140 m...

APO-B merupakan apolipoprotein terbesar dari fraksi Very Low Density Lipoprotein (VLDL). Hipertrigliseridemia membuat hati memproduksi lebih banyak VLDL dan LDL kaya trigliserida yang akan dihidrolisis untuk menghasilkan padat kecil (sd-LDL) melalui Cholesterol ester transfer protein (CETP) lipase hati. Sekitar 90% adalah LDL, rasio K-LDL/APO-B sebagai indikator partikel LDL. Penelitian ini dil...

Abstract Background The optimum lipid indexes, predicting the coronary lesion in postmenopausal women are not clear. Objective To evaluate predicter for routine and advanced tests. Method 300 were enrolled assigned into heart disease (CHD) Group (242), non-CHD (58). Routine indexes measured with standard laboratory test nuclear magnetic resonance (NMR) spectroscopy. correlation predictivities C...

The affinity of low density lipoprotein(LDL) to its receptor is very important, because most of LDL-uptake pathway is done by the LDL receptor and the change in size of LDL particle and the modification in its components may affect the LDL affinity for its receptor. In this study, the effects of a powerful lipid-soluble antioxidant “ubiquinol-10” have been investigated on the affinity of LDL to...

In this work, we investigate the Bell-Lavis model using entropic simulations for several values of energy parameters. The $T\times\mu$ phase diagram and ground state configurations are analyzed thoroughly. Besides, examine particle density specific heat behavior different chemical potential $\mu$ as functions temperature. We also obtain that maximize canonical probability temperature, enabling ...