Infections account for significant morbidity and mortality in liver cirrhosis and most are related to the gut microbiome. Fecal dysbiosis, characterized by an overgrowth of potentially pathogenic bacteria and a decrease in autochthonous non-pathogenic bacteria, becomes prominent with the progression of liver cirrhosis. In cirrhotic patients, disruption of the intestinal barrier causes intestina...

There is now evidence that major depression (MDD) is accompanied by an activation of the inflammatory response system (IRS) and that pro-inflammatory cytokines and lipopolysacharide (LPS) may induce depressive symptoms. The aim of the present study was to examine whether an increased gastrointestinal permeability with an increased translocation of LPS from gram negative bacteria may play a role...

work has focused on the role of the microflora in the etiology of obesity. In a rodent model, we have shown that an increase in gastrointestinal (GI) permeability is associated with weight gain whereas resistance diet-induced obesity is characterized by an intact intestinal barrier. A leaky gut allows bacterial products translocation to the circulation, notably pro-inflammatory lipopolysacchari...