Leonotis leonurus (L. leonurus) R. Br. (Lamiaceae) is used by healers in South Africa. The present study was conducted to determine if the L. leonurus effect on isolated rat heart is due to ionic changes in the perfusion fluid. Isolated rat hearts were perfused after Langendorff at 74 mmHg with modified Krebs–Henseleit buffer (K-H) and three test solutions: Ll (2 mg/ml dried crude aqueous leaf ...

Leonotisleonurus a shrub indigenous to Southern Africa is widely used in traditional medicine to treat a variety of conditions ranging from skin diseases and cough to epileptic fits and ‘heart problems’. Studies on the aqueous extract of the leaves have indicated cycloxegenase enzyme inhibitory activity and an antihypertensive effect. Five methanol leaf extract fractions (MLEa MLEe) of L. leonu...

In response to crowding, locusts develop characteristic black patterns that are well discernible in the gregarious phase at outbreaks. We report here a dark-color-inducing neuropeptide (dark-pigmentotropin) from the corpora cardiaca of two plague locusts, Schistocerca gregaria and Locusta migratoria. The chromatographic isolation of this neuropeptide was monitored by using a bioassay with an al...

Introduction . Natural deep eutectic solvents (DESs) are promising extractants for many biologically active substances from plant raw materials. They biodegradable, safe, stable, their production is affordable and easily feasible, the extraction efficiency comparable to known organic solvents. In this regard, interest in has been steadily growing recent years, they being used various fields of ...

Objective: To substantiate the possibility of using polarimetry to control quality tinctures as an additional pharmacopoeial method. Methods: The polarimetric method (POL-1/2, Atago, Japan, measurement accuracy of±0.002 °) was used measure optical activity (α motherwort, valerian and hawthorn tinctures. dynamic light scattering (DLS; Zetasizer Nano ZS, Malvern, UK) assess stability alcoholic aq...

BACKGROUND Leonurus heterophyllus sweet has been suggested to have cardioprotective effects against heart diseases, including ischemic diseases and ventricular remodeling. However, the active ingredients of the herb and the underlying mechanisms are poorly understood. The aim of the present study was to investigate the effects of stachydrine (STA), a major constituent of Leonurus heterophyllus ...