نتایج جستجو برای: leptin receptor transcript
تعداد نتایج: 631207 فیلتر نتایج به سال:
UNLABELLED We studied potential associations between the expression of leptin, leptin receptor (LEPR) and clinicopathological parameters of breast cancer, and the correlation of leptin with human telomerase reverse transcriptase (hTERT) and cyclooxygenase 2 (COX2) PATIENTS AND METHODS A total of 153 specimens were studied. Transcript levels were determined using quantitative polymerase chain ...
Leptin is a cytokine secreted from adipose tissue at a rate commensurate with the size of the body's fat stores. In addition to its anorectic and thermogenic central actions, leptin is known to act on peripheral tissues, including the pancreatic beta-cell where it inhibits insulin secretion and reduces insulin transcript levels. However, the role of leptin signalling through its full-length rec...
Leptin may act as a negative feedback signal to the hypothalamic control of appetite through suppression of neuropeptide Y (NPY) secretion and stimulation of cocaine and amphetamine regulated transcript (CART). We aimed at studying the effects of leptin, CART and NPY on the hypothalamic control of the pituitary-gonadal system. Pulsatile gonadotropin-releasing hormone (GnRH) secretion was studie...
aim : leptin is a 16 kda polypeptide hormone which secreted by adipose tissue and has an important role in energy balance, insulin pathway and inflammation, because of that it may play an important role in colorectal cancer (crc). leptin exerts its effect through the leptin receptor (lepr) a member of the class i cytokine receptor family. background : we have investigated whether glutamine to a...
It is estimated that up to 40-70% of obesities is attributable to genetic factors. Monogenic forms of obesity are uncommon. We present the first such reported case in Iran. The patient presented with a history of severe hyperphagia, rapid weight gain and recurrent infections. He was born after a normal pregnancy in a highly consanguineous marriage. His birth weight had been normal. At age ...
Osteoporosis is a systemic skeletal disease and there is a close relationship between the sympathetic nervous system (SNS) and bone metabolism. Leptin has been shown to regulate bone formation and bone resorption via the SNS. However, the effect of SNS on leptin signaling has not been clearly understood. In the present study, we studied the effect of propranolol on ovariectomy-induced osteoporo...
Mercer, Julian G., Kim M. Moar, Alexander W. Ross, Nigel Hoggard, and Peter J. Morgan. Photoperiod regulates arcuate nucleus POMC, AGRP, and leptin receptor mRNA in Siberian hamster hypothalamus. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 278: R271–R281, 2000.—Siberian hamsters decreased body weight by 30% during 18 wk in short day (SD) vs. long day (LD) controls. Subsequent imposed ...
OB-R is a high affinity receptor for leptin, an important circulating signal for the regulation of body weight. We identified an alternatively spliced transcript that encodes a form of mouse OB-R with a long intracellular domain. db/db mice also produce this alternatively spliced transcript, but with a 106 nt insertion that prematurely terminates the intracellular domain. We further identified ...
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