Protein tyrosine phosphatase 1B (PTP1B) contributes to leptin resistance by inhibiting intracellular leptin receptor signaling. Mice with whole body or neuron-specific deletion of PTP1B are hypersensitive to leptin and resistant to diet-induced obesity. Here we report a significant increase in PTP1B protein levels in the mediobasal hypothalamus (P = 0.003) and a concomitant reduction in leptin ...

Aims Acquired childhood obesity is becoming increasingly apparent with the changes in children`s life-style and eating environment, which become a severe social and medical problem. Our previous studies have found that the leptin concentrations were high in obese children, supporting that leptin resistance is a main mechanism of childhood obesity. The suppressor of cytokine signaling 3 (SOCS3) ...

Obesity is associated with metabolic syndrome, such as diabetes, hypertension, and hyperlipidemia. Therefore, drug development for the treatment of obesity is needed. Leptin is an anti-obesity hormone that inhibits food intake and increases energy metabolism, and, as such, treatments involving leptin were expected to be beneficial for obesity; however, since most obese patients are in a state o...

Pregnancy in rats is associated with hyperphagia, increased fat deposition, and elevated plasma leptin concentrations. Elevated leptin would be expected to inhibit food intake, but hypothalamic leptin resistance develops around midpregnancy, allowing hyperphagia to be maintained and excess energy to be stored as fat in preparation for future metabolic demands of lactation. To investigate the ho...

Comparison of Concurrent Aerobic, Resistance and Combination (Aerobic + Resistance) Training on Serum Levels Leptin, Atherogenic Index Plasma Cardiovascular Risk Factors in Obese Inactive Student Girls

Obesity is often associated with leptin resistance, which leads to a physiological system with high leptin concentration but unable to respond to leptin signals and to regulate food intake. We propose a mathematical model of the leptin-leptin receptors system, based on the assumption that leptin is a regulator of its own receptor activity, and investigate its qualitative behavior. Based on curr...

Intrauterine growth restriction (IUGR) is closely linked with metabolic diseases, appetite disorders and obesity at adulthood. Leptin, a major adipokine secreted by adipose tissue, circulates in direct proportion to body fat stores, enters the brain and regulates food intake and energy expenditure. Deficient leptin neuronal signalling favours weight gain by affecting central homeostatic circuit...

Background: To determine the relationship between serum leptin and insulin resistance in obese Pakistani subjects. Methods: In this observational study fifty healthy obese and overweight subjects were selected by nonprobability convenience sampling. Age, sex, height, weight and body mass index (BMI) of subjects were recorded. Fasting plasma glucose, serum leptin and insulin were measured. Fifty...

Conjugated linoleic acid (CLA) induces insulin resistance preceded by rapid depletion of the adipokines leptin and adiponectin, increased inflammation, and hepatic steatosis in mice. To determine the role of leptin in CLA-mediated insulin resistance and hepatic steatosis, recombinant leptin was coadministered with dietary CLA in ob/ob mice to control leptin levels and to, in effect, negate the ...

The rising global prevalence of obesity presents a diminished quality life and expectancy. Though myriad factors contributes to obesity, one the leading is excessive adipose tissue accumulation increases body’s production leptin satiety hormone resulting in resistance. Leptin resistance results increased vulnerability through improper regulation insulin, decline metabolic functions, decreased s...