AIMS To determine the acute lethal toxicity of a range of psychoactive substances in terms of the dose customarily used as a single substance for non-medical purposes. DESIGN AND METHOD A structured English-language literature search was conducted to identify experimental studies and clinical reports that documented human and non-human lethal doses of 20 abused substances that are distributed...

The effect of industrial sludge toxicity on the cell growth of a green paramecium, Paramecium bursaria was examined. P. bursaria cells were cultured in a lettuce medium supplemented with various concentrations of sludge suspension at 23 °C under LD (ligh and dark cycle) condition. Results suggested that P. bursaria proliferates normally even at 1.5% sludge suspension. However, 1.5x10 % sludge s...

Human toxicity Digoxin is a very toxic compound, with an estimated lethal dose being only a few milligrams. Nausea and vomiting are early signs of acute digoxin toxicity. Among other symptoms are gastro-intestinal tract (GIT) disorders, abdominal pain, diarrhea, hyperkalemia, and muscle pain and weakness. Since digoxin is a cardiac medicine, its overdoses can have severe and multiple effects on...

The acute oral toxicity test seeks to estimate the dose at which 50% of the organisms in adefined population will die (LD50) after exposure to a test material. The statistical basis for the classicstudy design was first described in the 1920s and remained in use until current times. In this test,groups of animals were administered varying doses of test material, and a dosed animal either lived ...

Every year thousands of new substances are synthetized and marketed. Either by regulatory demands or scientific purposes, these substances should all be tested. The determination of lethal concentration (LC) in a given population after toxicity testing in the laboratory is still the best way to establish and compare toxicity. In this technical note, we propose an R function to estimate LC with ...

The estuarine planktonic copepods have a wide geographical distribution and commendable tolerance to various kinds of contaminants. The primary aim of the present study was to contrast the impacts of model POPs (TBBPA and HBCD) on three common estuarine planktonic copepods (Oithona similis, Acartia pacifica and Pseudodiaptomus inopinus) and establish a protocol for the assessment of acute toxic...

Acute toxicity tests for the pesticides endosulfan and malathion on the larvae of Chironomus ramosus were conducted. Median Lethal Concentration (LC50) values of endosulfan were 0.55 x 10(-2), 0.16 x 10(-2), 0.089 x 10(-2) and 0.036 x 10(-2) ppb respectively, while those for malathion were 0.139 x 10(-2), 0.054 x 10(-2), 0.019 x 10(-2) and 0.0032 x 10(-2) ppb respectively, at 24, 48, 72 and 96 ...

Anthrax lethal toxin, composed of protective antigen and lethal factor, was tested for cytotoxicity to human melanoma cell lines and normal human cells. Eleven of 18 melanoma cell lines were sensitive to anthrax lethal toxin (IC(50) < 400 pmol/L) and 10 of these 11 sensitive cell lines carried the V599E BRAF mutation. Most normal cell types (10 of 15) were not sensitive to anthrax lethal toxin ...

Lethal and sublethal effects of ammonia toxicity to juvenile barramundi (Lates calcarifer) were investigated under laboratory conditions following the OECD guidelines for testing of chemicals. Acute toxicity was tested in a static nonrenewal system at pH 9.0 and temperature around 29 degrees C. The 24-, 48-, and 96-h LC(50) values for barramundi were 3.89, 3.67, and 3.31 mg total ammonia N L(-1...

Imidacloprid, one of the most commonly used insecticides, is highly toxic to bees and other beneficial insects. The regulatory challenge to determine safe levels of residual pesticides can benefit from information about the time-dependent toxicity of this chemical. Using published toxicity data for imidacloprid for several insect species, we construct time-to-lethal-effect toxicity plots and fi...