Sea weeds belonging to the Rhodophyceae (red algae) are an important source of bio active substances medicinal value. Many these used in drug development treat diseases caused by bacterial and fungal infections, inflammation, pain, arthritis, as well cancerous diseases. The paper chromatographic studies reveals that Grateloupia filicina contained photosynthetic pigment carotene Gracelaria corti...

In previous reports (I, 2), data were presented on the growth response of a leucineless mutant (strain 679-680)’ of Escherichia coli strain K-12 to various L-leucine peptides. Measurement of the extent of bacterial growth after 24 hours incubation showed that, at low concentrations, the peptides were almost as effective in the stimulation of growth as was L-leucine; at high concentrations, howe...

We have previously shown that a physiological increase in plasma leucine for 60 and 120 min increases translation initiation factor activation in muscle of neonatal pigs. Although muscle protein synthesis is increased by leucine at 60 min, it is not maintained at 120 min, perhaps because of the decrease in plasma amino acids (AA). In the present study, 7- and 26-day-old pigs were fasted overnig...

Dietary leucine has been suspected to play an important role in insulin release, a hormone that controls satiety and metabolism. The mechanism by which insulin-producing cells (IPCs) sense leucine and regulate insulin secretion is still poorly understood. In Drosophila, insulin-like peptides (DILP2 and DILP5) are produced by brain IPCs and are released in the hemolymph after leucine ingestion. ...

Incorporation of radiolabeled precursors into muscle proteins was studied in isolated rat hemidiaphragms. A mixture of three branched-chain amino acids (0.3 mM each) added to media containing glucose stimulated the incorporation of [14C]lysine into proteins. When tested separately, valine was ineffective, isoleucine was inhibitory, but 0.5 mM leucine increased the specific activity of muscle pr...

Plant proteins with domains rich in leucine repeats play important roles detecting pathogens and triggering defense reactions, both at the cellular surface for pattern-triggered immunity cell to ensure effector-triggered immunity. As intracellular parasites, viruses are mostly detected intracellularly by a nucleotide binding site leucine-rich but receptor-like kinases repeats, known localize su...

The leucine zipper (ZIP) motif consists of a periodic repetition of a leucine residue at every seventh position and forms an a-helical conformation, which facilitates dimerization and in some cases higher oligomerization of proteins. Inmany eukaryotic gene regulatory proteins, the ZIP motif is flanked at its N-terminus by a basic region containing characteristic residues that facilitate DNA bin...

Five components of leucine transfer ribonucleic acid in Escherichia coli separated on a reversed phase column were charged with radioactive leucine. Each labeled leucyltRNA was subjected to an exchange reaction with unlabeled E. coti tRNA in which the labeled leucine could be transferred from one leucine tRNA to another. The ‘exchange product, when analyzed on methylated albumin-Kieselguhr colu...

ROSENTHAL, J., A. ANGEL, AND J. FARKAS. Metabolic fate of leucine: a sign$kant sterol precursor in adipose tissue and muscle. Am. J. Physiol. 226(2) : 411-418. 1974.-The quantitative significance of muscle and adipose tissue as extrahepatic sites of leucine metabolism was studied. The rate of leucine conversion to either CO* or total lipid expressed per gram wet weight of tissue was adipose tis...

The initial observation of Cochrane, Payne, Simpkiss and Woolf, who described the hypoglycemic effect of L-leucine in certain patients with idiopathic infantile hypoglycemia (1), has been repeatedly confirmed. (2-6). L-leucine has also produced a hypoglycemic effect in certain patients with functioning islet cell tumors of the pancreas (7). Not all patients with these clinical syndromes respond...