PURPOSE OF THE STUDY The present study was conducted to estimate the serum levels of Circulating Immune Complexes in patients with Oral Leukoplakia ,Oral sub mucous fibrosis and normal subjects and correlate these values with the clinical grades of the diseases. MATERIALS AND METHODS The study consisted of 25 Oral Leukoplakia patients, 25 Oral sub mucous fibrosis patients and 25 Normal subjec...

OBJECTIVE To observe the effect of Erigeron breviscapus (Vant) Hand Mazz (HEr) in impeding oral leukoplakia carcinogenesis, and to seek effective Chinese herb medicine that can impede precarcinoma of oral mucosas. METHODS 132 golden hamsters were randomly divided into model group (60 animals), HEr group (60 animals), and control group 12 animals. Salley's leukoplakia carcinogenesis model of g...

OBJECTIVES Oral leukoplakia is a precancerous lesion of the oral mucosa. The upregulation of Ki67 and cyclooxygenase-2 has been reported in both dysplastic and non-dysplastic tissues. The aim of this clinicopathological study was to investigate the prognostic value of Ki67 and cyclooxygenase-2 expression for oral leukoplakia. MATERIAL AND METHODS A total of 50 samples were investigated and th...

the purpose of the present study was to estimate the frequency of hpv dna in four groups of oral lesions, including oral squamous cell carcinoma. sixty paraffin-embedded oral tissue samples were examined for the presence of hpv dnas using the pcr technique. these specimens were obtained from patients with oral squamous cell carcinoma (oscc), leukoplakia, oral lichen planus (olp), and pyogenic g...

The aim of the present study was to evaluate the definition of oral leukoplakia, proposed by the WHO in 2005 and taking into account a previously reported classification and staging system, including the use of a Certainty factor of four levels with which the diagnosis of leukoplakia can be established. In the period 1997-2012 a hospital-based population of 275 consecutive patients with a provi...

Background: Oral leukoplakia is a potentially malignant disorder that in a small but significant proportion of cases changes into oral cancer. Literature review suggests the association of inflammatory mediator such as cyclooxygenase-2(COX-2) with oral cancer. Expression of COX-2 gene in the oral potentially malignant disorders and oral cancer may add on a light to the existing diagnostics and ...

PURPOSE Morsicatio mucosae oris (MMO) presents as white papules and plaques that may resemble leukoplakia, and are often biopsied. The objective of this study is to document the clinical features and histopathology of MMO and to reevaluate the prevalence of dysplasia and/or cancer when this frictional keratosis is removed from the category of leukoplakia. MATERIALS AND METHODS Cases that were...

Management of potentially malignant disorders such as leukoplakia depends onearly interception &prevention of malignant transformationwhich includes several factors such as age of patients, systemic factors ,history of habits ,size & site of lesion ,its type & clinical features ,natural history & histopathological features .This is achieved by habit counseling for tobacco dependence and use of ...

Definition Leukoplakia is the most common premalignant or "potentially malignant" lesion of the oral mucosa. Leukoplakia is a predominantly white lesion of the oral mucosa than cannot be clinicopathologically characterized as any other definable lesion. The term leukoplakia is a clinical descriptor only and should not be used once histological information is available. On the other hand, the te...

UNLABELLED Mast cell contribution to neoangiogenesis during tumorigenesis in oral squamous cell carcinoma is not determined yet. OBJECTIVES To associate numerical mast cell density (MCD) to numerical microvessel density (MVD) during the progression of oral leukoplakia without dysplasia and leukoplakia with dysplasia to squamous cell carcinoma (OSCC). MATERIALS AND METHODS MVD was analysed i...