BACKGROUND The live oral rotavirus (RV) vaccines have shown a reduced efficacy in Africa. Recent in vitro studies have shown binding of the RV surface protein (VP4) to histo-blood group antigens (HBGAs) in an RV genotype-dependent manner, suggesting them to be putative receptors for RV. The diversity of HBGA phenotypes in different ethnic populations, combined with prevalence/absence of specifi...

Recent studies have shown that children with blood group A have increased susceptibility to enterotoxigenic Escherichia coli (ETEC) diarrhea and that Lewis blood group "a" antigen (Le(a)) may be a candidate receptor for ETEC colonization factor (CF) antigen I (CFA/I) fimbriae. Based on these findings, we have attempted to determine if children with the Le(a+b-) phenotype may be more susceptible...

BACKGROUND In normal gastric epithelium, MUC5AC is detected in superficial epithelium associated with Lewis type 1 antigens and MUC6 is detected in antral glands with Lewis type 2. Therefore, the stomach constitutes an excellent model to examine the role of glycosyltransferases in determining the specificity of apomucin glycosylation. AIMS To determine the molecular basis of this association ...

adnexal tumors (ats) are primary skin tumors with benign or rarely, malignant behavior. they have been classified based on differentiation towards hair follicle, sebaceous, apocrine or eccrine gland. few large-scale studies have focused on ats. to determine the prevalence of ats and to assess clinical and histopathological trend of ats. a retrospective descriptive study of all ats diagnosed in ...

BACKGROUND The pulmonary phenotype in cystic fibrosis (CF) is variable; thus, environmental and genetic factors likely contribute to clinical heterogeneity. We hypothesized that genetically determined ABO histo-blood group antigen (ABH) differences in glycosylation may lead to differences in microbial binding by airway mucus, and thus predispose to early lung infection and more severe lung dise...

OBJECTIVE To determine whether non-secretion of blood group antigens is associated with respiratory virus diseases. DESIGN Study of secretor status in patients with respiratory virus diseases determined by an enzyme linked immunosorbent assay (ELISA) developed to identify Lewis (Le) blood group antigen phenotypes (Le(a) non-secretor; Le(b) secretor). SUBJECTS Patients aged 1 month to 90 yea...

Blood group-related glycans determining ABO and Lewis blood groups are known to function as attachment factors for most of the norovirus (NoV) strains. To identify binding specificity of each NoV, recombinant norovirus-like particles (VLPs) and human saliva samples with different ABO, Lewis phenotypes and secretor status have been commonly applied. When binding specificities of VLPs prepared fr...

diffusion flame in a dust cloud combustion in a counterflow configuration is investigated in this research. it is presumed that the fuel particles vaporize first to yield a gaseous fuel to oxidize with the gas phase. the reaction rate is assumed to be of the arrhenius type. conservation equations for the non-unity lewis number are solved and the flame temperature with the variations of differen...