In the developing and adult CNS multipotent neural stem cells reside in distinct niches. Specific carbohydrates and glycoproteins are expressed in these niche microenvironments which are important regulators of stem cell maintenance and differentiation fate. LewisX (LeX), also known as stage-specific embryonic antigen-1 or CD15, is a defined carbohydrate moiety expressed in niche microenvironme...

The localization of two carbohydrate antigens, I and sialyl I antigens, in the lungs of developing human embryos was investigated using specific monoclonal antibodies and compared with the distribution patterns of the known embryonic antigen, stage-specific embryonic antigen-1 (Lex hapten). When the future bronchi were actively developing from the bronchial buds in the lungs of 50- to 53-day-ol...

TC( c: [ "Es gibt" , NP(det: dies, num: pl, adj: AdjP(lex: 11), lex: Veranstaltung) ] ) TC( c: [ "Es gibt" , NP(det: dies, num: pl, adj: AdjP(lex: 11), lex: Veranstaltung) ] ) TC( c: [ "Es gibt", aN(l_11: Maskottchen, a_0: bDnx(l_11: dies), a_1: bADJnx(l_111: 11), fvp: Fvp(num: pl) ) ] ) TC( c: [ "Es gibt", aN(l_11: Maskottchen, a_0: bDnx(l_11: dies), a_1: bADJnx(l_111: 11), fvp: Fvp(num: pl) )...

A subset of human helper memory T cells is known to adhere to E-selectin expressed on cytokine-activated endothelial cells. However, sialyl Lex antigen, the carbohydrate ligand for E-selectin, has been hardly detectable on these cells, at least when typical anti-sialyl Lex antibodies were used for detection. One of the MoAbs (2F3, IgM), which we raised against a chemically synthesized sialyl Le...

Many different N-chloroethyl-N-nitrosourea (CENU) derivatives have been synthesized in an attempt to minimize carcinogenic activity while favoring antineoplastic activity. CENU derivatives linked to the dipeptide lexitropsin (lex) showed significant changes in groove- and sequence-selective DNA alkylation inducing thermolabile N3-alkyladenines (N3-Alkyl-As) at lex equilibrium binding sites. CEN...

The lexicographic order, being a total order, has found numerous applications in optimization problems requiring selection of the best solution with respect to some preference criteria. We study lexicographically maximal and minimal, under different permutations, integer points in a compact convex set X . New relationships are established between X ∩ Zn and discrete sets defined using the lex o...

PURPOSE Defining the cytotoxicity of individual adducts in DNA is necessary for mechanistic understanding of human brain tumor resistance to therapeutic alkylating agents and for design of DNA repair-related antiresistance strategies. Our purpose is to characterize the sensitivity of human glioma cells to methyl-lexitropsin (Me-lex), a sequence-specific alkylator that produces 3-methyladenine (...

LEX is a stream cipher proposed by Alex Biryukov. It was selected to phase 3 of the eSTREAM competition. LEX is based on the Advanced Encryption Standard (AES) block cipher and uses a methodology called ”Leak Extraction”, proposed by Biryukov himself. In this paper, we cryptanalyze LEX using two related keys. We have mounted a key recovery attack on LEX, which using 2 key streams yields a compl...

Me-lex, a methyl sulfonate ester appended to a neutral N-methylpyrrolecarboxamide-based dipeptide, was synthesized to preferentially generate N3-methyladenine (3-MeA) adducts which are expected to be cytotoxic rather than mutagenic DNA lesions. In the present study, the sequence specificity for DNA alkylation by Me-lex was determined in the p53 cDNA through the conversion of the adducted sites ...