Background Fire service workers often implement multiple duties in the emergency conditions, with such duties being mostly conducted in various ambient temperatures. Methods The aim of the current study was to assess the firefighters' physiological responses, information processing, and working memory prior to and following simulated firefighting activities in three different hot environments...

The nitrogen mustard derivatives of 4-phenylbutyric acid and L-phenylalanine, called chlorambucil (Chl) and melphalan (Mel), respectively, have been incorporated into several peptide hormones, including luteinizing hormone-releasing hormone (LH-RH). The alkylating analogues of LH-RH were prepared by linking Chl, as an N-acyl moiety, to the complete amino acid sequence of agonistic and antagonis...

nigella sativa (black seed) is an important medicinal herb with folkloric use in wide range of diseases. it is well studied for its biological activities. however, there is limited information regarding its effect on the male reproductive system. this study describes the effect of the aqueous extract of n. sativa (nse) on testicular steroidogenesis from mice leydig cells in vitro . mice testicu...

BACKGROUND Leydig cells are the primary source of testosterone in male vertebrates. The biosynthesis of testosterone in Leydig cells is strictly dependent on luteinizing hormone (LH). On the other hand, it can be directly inhibited by excessive glucocorticoid (Corticosterone, CORT, in rats) which is beyond the protective capability of 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) and...

Bovine thyroid-stimulating hormone (thyrotropin, TSH) has been separated into two different subunits by gel filtration in ammonium bicarbonate solution after prior treatment with 1 M propionic acid. The two subunits, which have been designated TSH-a! and TSH-0, resemble each other more closely in amino acid composition than do the two subunits of luteinizing hormone (LH, interstitial cell-stimu...

BACKGROUND Selective atrophy of hamstring components may result from muscle strain or graft harvesting for anterior cruciate ligament reconstruction. Assessment and rehabilitation that specifically targets medial (MH) or lateral (LH) hamstring components may improve patient outcomes. The purpose of this study was to evaluate effects of volitional tibial rotation medially (MR) versus laterally (...

The midcycle luteinizing hormone (LH) surge triggers several tightly linked ovarian processes, including steroidogenesis, oocyte maturation, and ovulation. We designed studies to determine whether epidermal growth factor receptor (EGFR)-mediated signaling might serve as a common regulator of these activities. Our results showed that EGF promoted steroidogenesis in two different in vitro models ...

Tsai, Shiow-Chwen, Chien-Chen Lu, Jiann-Jong Chen, Yu-Chung Chiao, Shyi-Wu Wang, Jiuan-Jiuan Hwang, and Paulus S. Wang. Inhibition of salmon calcitonin on secretion of progesterone and GnRH-stimulated pituitary luteinizing hormone. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E49–E55, 1999.—The effects of salmon calcitonin (sCT) on the production of progesterone and secretion of luteinizing hor...

The effects of salmon calcitonin (sCT) on the production of progesterone and secretion of luteinizing hormone (LH) were examined in female rats. Diestrous rats were intravenously injected with saline, sCT, human chorionic gonadotropin (hCG), or hCG plus sCT. Ovariectomized (Ovx) rats were injected with saline or sCT. In the in vitro experiments, granulosa cells and anterior pituitary glands (AP...