The confinement of molecular machines into nanostructured cages and controlling their functions by external stimuli holds great potential for the creation smart functional materials that imitate embodied intelligence biological processes. Herein, we report construction a supramolecular rotor in porous Zn-metallated porphyrinic cage (1) encapsulation tetrazine-based linear axle (LA) via metal-li...

PURPOSE Tumor cell targeting is a promising strategy for enhancing the therapeutic potential of chemotherapy agents. Polyethylene glycol (PEG)-coated (sterically stabilized) liposomes show enhanced accumulation on the surface of tumors, but steric hindrance by PEGylation reduces the association of the liposome-bound ligand with its receptor. To increase folate receptor (FR) targeting, we optimi...

A new method is developed to enhance the gas separation properties of mixed matrix membranes (MMMs) by interior modification of an inorganic nano-porous particle. Ship-in-a-bottle (SIB), as a novel synthesis strategy, is considered to encapsulate a polyaza macrocyclic Ag-ligand complex into the zeolite Y, which is resulted in a new host-guest nano-composite. It is consequently incorporated into...

Molecular copper water oxidation electrocatalysts have been extensively studied in recent years for their potential use artificial photosynthetic systems solar energy conversion. Although ligand modification and its ability to influence catalytic properties is a key advantage of molecular systems, there are, as yet, few examples systematic studies these effects. Our oxidatively resistant pyalk ...

BACKGROUND Site-selective modification of proteins at two separate locations using two different reagents is highly desirable for biosensor applications employing fluorescence resonance energy transfer (FRET), but few strategies are available for such modification. To address this challenge, sequential selective modification of two cysteines in glucose/galactose binding protein (GGBP) was demon...

Transmembrane chemoreceptors are central components in bacterial chemotaxis. Receptors couple ligand binding and adaptational modification to receptor conformation in processes that create transmembrane signaling. Homodimers, the fundamental receptor structural units, associate in trimers and localize in patches of thousands. To what degree do conformational coupling and transmembrane signaling...

In central nervous system (CNS)-directed gene therapy, efficient targeting of brain parenchyma through the vascular route is prevented by the endothelium and the epithelium of the blood-brain and the blood-cerebrospinal fluid barriers, respectively. In this study, we evaluated the feasibility of the combined genetic and chemical adenovirus capsid modification technology to enable transcellular ...