An efficient approach for the synthesis of a series of S-acyl peptides containing internal cysteine residues has been developed and the chemical long-range ligation of these S-acyl peptides via 5-, 8-, 11- and 14-membered cyclic transition states has been investigated. Our results include the first examples of successful isopeptide ligations starting from S-acyl peptides containing non-terminal...

this study was designed to investigate the role of gabab receptor agents on imipramine-induced antinociception in ligated and non-ligated mice using hot-plate test. the data showed that different doses of morphine (3, 6, and 9 mg/kg) induced a dose-dependent antinociception in ligated and non-ligated mice. however, the opioid response was decreased in ligated animals. intracerebroventricular (i...

pseudo-aneurysm of the femoral artery is the most common arterial complication in drug injecting abusers. scholars in vascular surgery have published debating statements regarding techniques of successful surgical management during last two decades. we present the results of simple arterial ligation in a series of 32 patients presenting with infected femoral pseudo-aneurysm. most of the patient...

MANY of our research studies on dogs have required the repeated removal of large liver samples which must be processed immediately for biochemical or other studies. A simplified technique has been used. The tip of one of the lobes of the liver is gently grasped with a sponge (Fig. 1a). A 0 cotton ligature is placed as far back as is necessary to obtain the required size biopsy. The ligature is ...

objective(s): neurotrophins (nts) exert various effects on neuronal system. growing evidence indicates that nts are involved in the pathophysiology of neuropathic pain. however, the exact role of these proteins in modulating nociceptive signaling requires being defined. thus, the aim of this study was to evaluate the effects of spinal nerve ligation (snl) on nts activation in the lumbar dorsal ...

Objective: To compare the blood loss in bipolar diathermy versus suture ligation for hemostasis patients presented with chronic tonsillitis Material and methods: We conducted this randomized controlled at ENT Department Sheikh Zayed Hospital Rahim Yar Khan from April, 2022 to September, 2022. Total 70 presenting divided two groups equally. Patients were treated procedures ligation. Mean operati...

a prospective, randomized trial on 416 consecutive cases of appendicectomies was carried out in which half of the cases had simple ligation of the stump and the rest had invagination of the stump in addition. the two groups were matched for age, sex, state of personal hygiene and nutrition. the incidence of wound infection, and early and late post-operative complications remained comparable bet...