background:  the aim of this study was to evaluate whether higher serum levels of igf-i in the acute phase of ischemic stroke are associated with less severe strokes and better functional outcome in a period of one year follow up. methods: from october 2014 to august 2015, patients with the diagnosis of acute ischemic stroke admitted to the stroke unit of firoozgar hospital entered this prospec...

results 100 patients with cirrhosis with a male to female ratio of 63:37 and a mean age of 44.4 ± 15 years were enrolled in the study. median igf-1 was 92.95 ± 91.51 ng/ml. 14 patients (14%) had igf-1 within normal limits while 86 patients (86%) had abnormal igf-1 levels. in all patients the correlation coefficient between igf-1 and meld was -0.317 (p = 0.001) and 0.478 between igf-1 and child-...

We have reported that integrins crosstalk with growth factors through direct binding to growth factors (e.g., fibroblast growth factor-1, insulin-like growth factor 1 (IGF1), neuregulin-1, fractalkine) and subsequent ternary complex formation with cognate receptor [e.g., integrin/IGF1/IGF1 receptor (IGF1R)]. IGF1 and IGF2 are overexpressed in cancer and major therapeutic targets. We previously ...

Insulin-like growth factor-1 (IGF-1) effects on aging and neurodegeneration is still controversial. However, it is widely admitted that IGF-1 is involved in the neuroinflammatory response. In peripheral tissues, several studies showed that IGF-1 inhibited the expression of inflammatory markers, although other studies concluded that IGF-1 has proinflammatory functions. Furthermore, proinflammato...

The prevalence of obesity, metabolic syndrome, and type 2 diabetes mellitus, and the associated cardiac pathologies are rising to alarming levels. Conventional medical therapies for the prevention and treatment of cardiomyopathy are less effective in patients with these metabolic disorders, and this is attributed, at least in part, to a limited understanding of the cellular and genetic mechanis...