tion. Conversely, a semi-rigid, optimized acentric organization results in coherent second harmonic emission at the supramolecular level, the corresponding intensity from the dendrimer solution being almost proportional to Nmonomerábmonomerñ. The Nmonomer dependence assumes a linear additive model, whereby the individual sub-units follow an interaction-free oriented gas behavior. We have, there...

In this paper, we show that PtAu and PdAu random alloy dendrimer-encapsulated nanoparticles with an average size of ∼1.6 nm have different catalytic activity trends for allyl alcohol hydrogenation. Specifically, PtAu nanoparticles exhibit a linear increase in activity with increasing Pt content, whereas PdAu dendrimer-encapsulated nanoparticles show a maximum activity at a Pd content of ∼60%. B...

Degradable dendrimer-like PEOs were designed using an original ABC-type branching agent featuring a cleavable ketal group, following an iterative divergent approach based on the anionic ring opening polymerization (AROP) of ethylene oxide and arborization of PEO chain ends. A seventh generation dendrimer-like PEO carrying 192 peripheral hydroxyls and exhibiting a molar mass of 446 kg · mol(-1) ...

In view of the enhanced generation of folate receptors in cancerous cells and diseases linked to the deficiency of folic acid, such as anemia, mental devolution, congenital malformation, etc., the development of a simple method for the ultra-sensitive determination of folic acid remains a long-standing issue for practical applications in medicine and biotechnology. Thus, the proposed luminescen...

Synthetic polymers of a specific shape and size play major role in drug delivery systems. Dendrimers are unique synthetic macromolecules of nanometer dimensions with a highly branched structure and globular shape with potential applications in gene and drug delivery. We examine the interaction of several dendrimers of different compositions mPEG-PAMAM (G3), mPEG-PAMAM (G4) and PAMAM (G4) with h...

The aim of this study was to investigate the effect of Poly(amidoamine) (PAMAM) dendrimers on corneal permeation of puerarin (PUE). Permeation studies were performed using excised cornea of rabbits by a Valia-Chien diffusion apparatus. Drug-treatment studies were carried out by measuring the penetration of puerarin on cornea in PAMAM-PUE physical mixture or PAMAM-PUE complex, and cornea-treatme...

Given the exceptional potential of dendrimer macromolecules for numerous biomedical applications, we performed extensive coarse-grained molecular dynamics simulations to investigate the role of electrostatic interactions in complexes comprised of cationic dendrimers with oppositely charged linear polyelectrolytes. For this purpose, we varied the nature of polyelectrolytes by considering both mo...

Unprecedented 3D hexa-adducts of [60]fullerene peripherally decorated with twelve tryptophan (Trp) or tyrosine (Tyr) residues have been synthesized. Studies on the antiviral activity these novel compounds against HIV and EV71 reveal that they are much more potent equally active than previously described dendrimer prototypes AL-385 AL-463, which possess same number Trp/Tyr periphery but attached...

Introduction Since their discovery polyhedral oligosilsesquioxanes (POSS) have found an ever increasing number of applications in material science, catalysis, as building blocks for dendrimers and only recently biomedical use (e.g. as drug carrier systems) were reported as well. In the last two years studies of silsesquioxane based contrast agents (CA) for MRI were published [1,2] in which the ...