background & objective: autoimmune bullous diseases are associated with autoimmunity against structural components in the skin and mucous membranes. autoantibodies are against the intercellular junctions in pemphigus disease and hemidesmosomal unchoring complex in pemphigiod diseases and epidermolysis bullosa aquisita. the tissue-bound and circulating serum autoantibodies can be detected wi...

Background and aim: Skin diseases among pilgrims are considered to be one of the possible health problems. Data supporting this observation are scanty. The aim of this study was to report the most common skin diseases seen in Hajj season. Materials and Methods: Data regarding skin diseases were collected from piligrims whom were examined and diagnosed clinically at the skin clinics of Iran in S...

Background: Prolactin, a neurohormone, can act as a stimulator of immunity in a number of autoimmune diseases and its high levels have been shown in these diseases. Objective: This study was designed to discover the possible role of prolactin in autoimmune blistering skin diseases. The main goal was to compare the serum prolactin levels and the frequency of hyperprolactinemia in autoimmune skin...

What shall we do when we have done everything we could for the diagnosis and treatment of a patient, but were not successful? What shall we do when there is no definite treatment for a patient? What shall we do when we have no diagnosis or treatment for a patient? Some useful suggestions are presented here to get rid of these situations.

Scleroderma is a rare disease. Approximately 80% of patients are females, and one-half present before the age of 40. Some studies suggest a higher incidence and severity of disease in black females than in whites. Scleroderma affect approximately 20 new patients per million per year and has an estimated prevalence of approximately 250 patients per million in the United States, the synonyms from...

a 16 year old woman with tangier disease in palatine tonsils is reported. she has recurrent sore throat. in physical examination the palatine tonsils are hypertrophied and has very yellowish points. the facial skin is yellowish but the skin of another areas of body is normal. after tonsillectomy the pathologist report tangier disease in palatine tonsils

 Background: Behçet’s disease (BD) is a multi-system inflammatory vascular disorder with auto immunity background. It is a genetic disease that may be affected by environmental factors. Behçet’s disease may involve different organs like urogenital, skin, eyes and gastrointestinal system. According to geographic area and genetic predisposition, prevalence of the disease is different. The aim of...