Nanostructured lipid carriers (NLCs), a lipid based colloidal carrier system, offer many advantages such as increase the solubility, improves the bioavailability and therapeutic efficacy. Incorporation of liquid lipid can improve the drug loading capacity in the NLCs. Valsartan is an antihypertensive drug with low oral bioavailability ranging from 10-35% because of poor solubility and extensive...

Oral route is the most common and convenient route for drug delivery, but some drugs are not given by this route. This route is most common problem is low bioavailability .The various challenges faced by the pharmaceutical scientists leads to the improve bioavailibilityty enhance the approach of self emulsifying drug delivery system. It has gained exposure of their ability to increase solubilit...

Essential oils are complex blends of a variety of volatile molecules such as terpenoids, phenol-derived aromatic components, and aliphatic components having a strong interest in pharmaceutical, sanitary, cosmetic, agricultural, and food industries. Since the middle ages, essential oils have been widely used for bactericidal, virucidal, fungicidal, antiparasitical, insecticidal, and other medici...

A new frontier in the administration of therapeutic drugs to veterinary species is transdermal drug delivery. The primary challenge in developing these systems is rooted in the wide differences in skin structure and function seen in species ranging from cats to cows. The efficacy of a transdermal system is primarily dependent upon the barrier properties of the targeted species skin, as well as ...

The ability of ethanol to dissolve wax compounds, as an alternative to traditional lipid solvents, was investigated for the recovery of cuticular lipids from biomass. The solubilities of fatty esters with carbon chain lengths from 40 to 54 were measured in ethanol over a temperature range of 30–807C. The greatest increase in solubility was observed between 407 and 607C for the long chain waxes ...

BACKGROUND Micelle formation of cholesterol with lecithin and bile salts is a key process for intestinal absorption of lipids. Some dietary fibers commonly used to reduce the lipid content in the body are thought to inhibit lipid absorption by binding to bile salts and decreasing the lipid solubility. Amongst these, α-cyclodextrin (α-CD) is reportedly one of the most powerful dietary fibers for...

Palm-based lipid nanoparticle formulation loaded with griseofulvin was prepared by hot homogenisation and a solvent-free method. The optimum griseofulvin loaded lipid nanoparticles were prepared via stages of optimisation, such as high pressure homogenisation (HPH) parameters, lipid and surfactant screening and selection of suitable lipid to surfactant ratios; followed by photon correlation stu...

Identification of the usefulness of lipid-based formulations (LBFs) for delivery of poorly water-soluble drugs is at date mainly experimentally based. In this work we used a diverse drug data set, and more than 2,000 solubility measurements to develop experimental and computational tools to predict the loading capacity of LBFs. Computational models were developed to enable in silico prediction ...

The present review compiles the applications of lipid nanoparticles mainly solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the delivery of pharmaceutical actives. The attempts to overcome the low solubility and bioavailability of some drugs by their incorporation into lipid nanocarriers have been summarized. A special focus of this review is on different routes of ad...