The distribution of alpha-casein, bovine serum albumin (BSA), myoglobin and recombinant protective antigen (rPA) in mono-valent and combination vaccines containing aluminum hydroxide adjuvant was studied by fluorescence microscopy and flow cytometry. Green and red fluorescent probes were conjugated to the antigens. Adsorption isotherms of the fluorescently labeled proteins to aluminum hydroxide...

the kinetic of the heterogeneous chemical reaction of aluminum hydroxide and fluosilicic acid was studied. it was found that the diffusion of the reactants through the porous silica coating to the aluminum hydroxide surface and the interfacial chemical reaction between the diffusing reactant and aluminum hydroxide platelets control the overall reaction rate. these two phenomena were studied and...

The reaction of Nevada opal with calcium hydroxide, potassium and lithium hydroxide solutions was investigated. In addition opal was exposed to a combined solution of these three hydroxides. The progress of the three reactions was followed using X-ray Diffraction (XRD), 29 Si Nuclear Magnetic Resonance (NMR) and Scanning Electron Microscopy (SEM). The XRD results indicated the presence of a low...

One of the first subjects introduced to students of environmental chemistry is the aqueous chemistry of aluminum. This metal is the third most abundant element in the shallow Earth, where it hydrolyzes in water to produce a rich array of solute molecules and solids, including clays and aluminum hydroxide phases. Although these materials are ubiquitous, we are just beginning to understand the ki...

In this paper, the structure of SAW has been studied. In previous work in SAW, materials such as lithium niobium, lithium tantalite and gallium nitride were used in the structure of SAW, and thus had a low operating frequency and the highest reported operating frequency was about 4 GHz. In this paper, aluminum nitride and gallium nitride in the SAW structure are used in combination. The electro...

The kinetic of the heterogeneous chemical reaction of aluminum hydroxide and fluosilicic acid was studied. It was found that the diffusion of the reactants through the porous silica coating to the aluminum hydroxide surface and the interfacial chemical reaction between the diffusing reactant and aluminum hydroxide platelets control the overall reaction rate. These two phenomena were studied...

Aluminum compounds were first identified as adjuvant over 90 years ago [1]. Adjuvants (immunopotentiators or immuno modulators) in vaccine formulations aim to enhance, accelerate and prolong the specific immune response towards the desired response to vaccine antigens. Advantages of adjuvants include the enhancement of the immunogenicity of antigens, modification of the nature of the immune res...

Triazolam 0.5 mg was administered to 11 dialysis patients and 11 age, weight and sex matched controls. Peak plasma concentrations (Cmax) were higher in control subjects, but there were no other differences between the groups. When dialysis patients took triazolam with 3600 mg aluminum hydroxide suspension, Cmax and AUC were increased into the range observed in control subjects. It appears that ...

ONS-3010 is being developed by Oncobiologics Inc. (Cranbury, NJ, USA) as a biosimilar of Humira®. This randomized, double blind, single-center phase I study (EudraCT registration # 2013-003551-38) was performed to demonstrate pharmacokinetic (PK) biosimilarity between two reference products (Humira® EU and US) and ONS-3010 in healthy volunteers, and to compare the safety and immunogenicity prof...

The serological response and efficacy of Bacillus anthracis recombinant protective antigen (rPA) vaccines formulated with aluminum hydroxide adjuvant, either with or without formaldehyde, were evaluated in rabbits. Rabbits that had been injected with a single dose of 25 microg of rPA adsorbed to 500 microg of aluminum in aluminum hydroxide gel (Alhydrogel) had a significantly higher quantitativ...