: Cardiopulmonary surgery is associated with risk of liver dysfunction due to hypoperfusion, release mediators by macrophages and drug induced injury.

Oxygen is an essential part of the most important metabolic pathways in aerobic organisms. Oxygen delivery is merely dependent on blood, rendering blood loss a devastating event. Traumatic pre-hospital liver bleeding is a major cause of early trauma deaths in human and animals, with no established therapeutic method yet. Increasing intra-abdominal pressure (IAP) has been shown to reduce liver b...

liver injury occurs with many drugs; therefore, a thorough work up is important for establishing the diagnosis. we report a case of trifluoperazine-induced cholestatic jaundice. a 44-year old male with schizoaffective disorder developed an increase in liver enzymes and jaundice after starting treatment with trifluoperazine. workup for other potential etiologies was negative.

Objective(s): Interleukin-36 receptor antagonist (IL-36Ra) is a new member of the IL-1 family that exhibits anti-inflammatory activity in a variety of inflammatory and immune diseases. Our purpose was to determine the effect of IL-36Ra on liver injury in a mouse hepatitis model induced by concanavalin A (ConA). Materials and Methods: Mic...

introduction liver abscess developing during hospital stay in pediatric patients on dialysis for acute kidney injury has been previously unreported. impaired immunity, prolonged use of antibiotics, diabetes and malnutrition predispose to liver abscess in chronic hemodialysis patients. case presentation we reported a case of liver abscess developing in a 6-year-old boy admitted with sepsis and m...

Background Liver ischemia/reperfusion (I/R) injury is a complex and multifactorial pathophysiological process. It well recognized that the membrane permeability transition pore (mPTP) opening of mitochondria plays crucial role in cell death after I/R injury. Cyclophilin D (CypD) critical positive regulator mPTP. However, effect CypD on pathogenesis liver whether potential therapeutic target are...

Liver being vulnerable to exogenous substances makes disease associated with it a matter of worldwide concern. Several research thus focus on hepatoprotection .Preventive and therapeutic activity plants as hepatoprotective agent is topic interest for researchers. Hepatotoxic agents like carbon tetrachloride, paracetamol, isoniazide etc. increase the serum biomarkers liver where ALT more specifi...