tramadol is a synthetic, centrally acting opioid analgesic that has the best analgesic efficacy without excessive sedation and significant side effects in the postoperative pain relief in dogs. objectives: in this study, hematological and biochemical changes due to short usage of tramadol were assessed in clinically healthy dogs. methods: for this purpose, eighteen male mongrel dogs aged 14 to ...

N-Hydroxyphenacetin was activated to a mutagen in the Salmonella-Ames test by rabbit liver acyltransferase, rat liver cytosol, and rat liver microsomes. N-[ring]3H]-Hydroxyphenacetin was bound to transfer RNA when activated by acyltransferase from rabbit or rat liver or rat liver microsomes. The acyltransferase-catalyzed binding was not inhibited by paraoxon, a deacetylase inhibitor. The use of...

Rabbit antibodies against the microsome fractions of a chemi cally induced rat hepatoma and of normal rat liver were com pared by the paired label radioantibody technic. The antihopatoma antibodies were labeled with 125Iand the anti-normal-liver antibodies were labeled with 131I.The 2 were mixed and then in jected or treated in vitro simultaneously. The 2 antibodies differed in vivo in their lo...

Bupropion's metabolism and the formation of hydroxybupropion in the liver by cytochrome P450 2B6 (CYP2B6) has been extensively studied; however, the metabolism and formation of erythro/threohydrobupropion in the liver and intestine by carbonyl reductases (CR) has not been well characterized. The purpose of this investigation was to compare the relative contribution of the two metabolism pathway...

Bupropion’s metabolism to form hydroxybupropion in the liver by CYP450 2B6 (CYP2B6) has been extensively studied, however, the metabolism to form erythro/threohydrobupropion in the liver and intestine by carbonyl reductases (CR) has not been well characterized. The purpose of this investigation was to compare the relative contribution of the two metabolism pathways of bupropion (by CYP2B6 and C...

The generation of free radicals by microsome-mediated redox cycling between catechol estrogens or diethylstilbestrol and their corresponding quinones has previously been demonstrated in vitro. However, the reaction of free radicals with DNA has not yet been detected in animals treated with estrogen and is the subject of this investigation. The reaction of guanine bases of DNA with hydroxyl radi...

Bupropion’s metabolism and the formation of hydroxybupropion in the liver by cytochrome P450 2B6 (CYP2B6) has been extensively studied; however, the metabolism and formation of erythro/ threohydrobupropion in the liver and intestine by carbonyl reductases (CR) has not been well characterized. The purpose of this investigation was to compare the relative contribution of the two metabolism pathwa...

backgrounds: g6pd deficiency is the most common enzymopathy of red blood cells. the clinical symptoms of favism are jaundice, hematuria and haemolytic anaemia that seem to affect liver and kidney in long term. thus we evaluate kidney and liver function of favism patients in an endemic area of the disease with a high rate of fava beans cultivation. methods: this study was performed on favism pat...