Saguling Reservoir is one of the reservoirs built in Citarum Watershed which quite polluted, and has a potential to contain heavy metals (such as Pb). The Pb will be concentrated body catfish (Pangasius djambal) commonly cultured reservoir long term accumulate. Liver an organ that accumulates most so it cause damage form necrosis, fibrosis, cirrhosis. This study aims analyze content liver its e...

Massive hepatic necrosis is a key event underlying acute liver failure, a serious clinical syndrome with high mortality. Massive hepatic necrosis in acute liver failure has unique pathophysiological characteristics including extremely rapid parenchymal cell death and removal. On the other hand, massive necrosis rapidly induces the activation of liver progenitor cells, the so-called "second path...

BACKGROUND To study the cause and outcome of ischemic liver necrosis and suggest treatment of these patients. METHODS Retrospective study of 13 patients with ischemic liver necrosis treated at our departments from 1990 until 1997. RESULTS Ischemic liver necrosis was caused by general hypoxia (n = 1) or acute arterial occlusion (n = 12) of the celiac and superior mesenteric artery (SMA, n = ...

AIM To evaluate if any association existed between the extent of hepatic necrosis in initial liver biopsies and patient survival. METHODS Thirty-seven patients with fulminant liver failure, whose liver biopsy exhibited substantial necrosis, were identified and included in the study. The histological and clinical data was then analyzed in order to assess the relationship between the extent of ...

This study aimed to evaluate the in-vitro and in-vivo biological activities of newly synthesized nanochelating based silver nanoparticles (AgNPs) in mouse model. Nanochelating technology was used to design and synthesize the AgNPs. The animals studies were including the lethal dose (LD50) determination by the intraperitoneal administration in mice, and determination of liver e...

This study aimed to evaluate the in-vitro and in-vivo biological activities of newly synthesized nanochelating based silver nanoparticles (AgNPs) in mouse model. Nanochelating technology was used to design and synthesize the AgNPs. The animals studies were including the lethal dose (LD50) determination by the intraperitoneal administration in mice, and determination of liver e...

PURPOSE Many chemical compounds and infectious agents such as viruses induce liver damage like necrosis or fulminant hepatic failure which is sometimes difficult to manage by medical therapies. The induced liver necrosis by carbon tetrachloride (CCl4) and thioacetamide (TAA) are exemplary models for experimental liver necrosis caused by oxygen free radicals. The aim of this study was to investi...

the study monitored the toxicity of environmentally relevant concentration of pesticides and metals in zebra fish danio rerio. zebra fish were exposed to environmentally relevant concentration of pesticides and metals for a period of 14 days. the individual and the combined toxicity of pesticides and metals were evaluated. the pesticides and metals treated groups showed histopathological altera...