Intrahepatic cholangiocarcinoma (ICH) is one of the most aggressive malignant neoplasms gastrointestinal tract, which accounts for 10–15% all primary liver tumors. Among risk factors ICH in Europe and Russia, diseases accompanied by formation concretions intrahepatic bile ducts, include Karoli's disease (KD), are importance. The article presents a clinical observation HPV that developed against...

A method of performing magnetization transfer contrast (MTC) using a pulse sequence based on a series of on-resonance binomial pulses preceding a conventional spin-echo sequence has been recently described. We investigated this technique in the evaluation of circumscribed hepatic neoplasms on a 0.5 T imager. Conventional spin-echo imaging was performed in 18 patients with hepatic neoplasms, 15 ...

OBJECTIVE To evaluate the frequency and outcome of liver transplantation for symptomatic, unresectable, benign hepatic neoplasms. DESIGN Retrospective study. SETTING Presbyterian University Hospital, a tertiary care referral center for liver transplantation affiliated with the University of Pittsburgh (Pa). PATIENTS All 3239 liver transplant recipients at the University of Pittsburgh from...

Isozymes of carbamyl phosphate synthetase (CPS), CPS I, a mitochondrial enzyme found exclusively in liver and involved in urea synthesis, and of CPS II, a soluble cytoplasmic enzyme widely distributed in animal tissues, were assayed in rat liver and in a series of rat liver neoplasms ranging widely in growth rate and degree of differentiation. CPS I was absent from fast-growing, poorly differen...

Primary and metastatic neoplasms of the liver account for more than a million deaths per year worldwide. Despite decades of research, effective novel therapies for these cancers are urgently needed. Oncolytic virotherapeutics represent a novel class of pharmacophore that holds promise for the treatment of hepatic neoplasms. Cancer-specific replication is followed by oncolysis, virus spreading a...