Alternative splicing, and specifically alternative exon inclusion, is one of the best studied mechanisms that create alternative isoforms. In its simplest form, alternative exon inclusion can be represented as exon skipping. Novel exon skipping events can be created through mutation events near and far from splice junctions, and thus may contribute to diseases, such as cancer. We systematically...

OBJECTIVE To examine whether television viewing, computer game playing or book reading during meals predicts meal skipping with the aim of watching television, playing computer games or reading books (media meal skipping). DESIGN A cross-sectional study was conducted using a standardized self-administered questionnaire. Analyses were controlled for age, gender and BMI. SETTING Data were obt...

BACKGROUND Adolescence is an important period since the establishment of dietary pattern can also affect the adulthood. This study aimed to estimate the overall prevalence of skipping breakfast among Iranian students. METHODS The international and national databases, including Medline, Scopus, Science Direct, Embase, Web of sciences, Google Scholar, MagIran, and SID were searched 1945-2016 as...

Eating breakfast is important for the health and development of children and adolescents. This paper reports on the findings of an Australian survey of 699 thirteen-year-olds concerning the extent of skipping breakfast. Results indicated that approximately 12% of the sample skipped breakfast. Gender was the only statistically significant sociodemographic variable, with females skipping at over ...

PURPOSE Recurrent MET exon 14 splicing has been revealed in lung cancers and is a promising therapeutic target. Because we have limited knowledge about the natural history of MET mutant tumors, the current study was aiming to determine the clinical and pathological characteristics in non-small cell lung cancers (NSCLC). RESULTS Twenty-three patients (1.3%) were positive for MET exon 14 skippi...

In Drosophila, the Gal4-UAS system permits a transgene to be expressed in the same pattern as a gene of interest by placing the Gal4 transcription factor under control of the gene's DNA regulatory elements. If these regulatory elements are not known, however, expression of Gal4 in the desired pattern may be difficult or impossible. To solve this problem, we have developed a method for co-expres...

Removing commercials from television programs is a much sought-after feature for a personal video recorder. In this paper, we employ an unsupervised clustering scheme (CM Detect) to detect commercials in television programs. Each program is first divided into Ws-minute chunks, and we extract audio and visual features from each of these chunks. Next, we apply k-means clustering to assign each ch...

As an alternative to walking and running, humans are able to skip. However, adult humans avoid it. This fact seems to be related to the higher energetic costs associated with skipping. Still, children, some birds, lemurs and lizards use skipping gaits during daily locomotion. We combined experimental data on humans with numerical simulations to test whether stability and robustness motivate thi...

Antisense oligonucleotide (AO)-mediated exon-skipping therapy is one of the most promising therapeutic strategies for Duchenne Muscular Dystrophy (DMD) and several AO chemistries have been rigorously investigated. In this report, we focused on the effect of 2'-O-methoxyethyl oligonucleotides (MOE) on exon skipping in cultured mdx myoblasts and mice. Efficient dose-dependent skipping of targeted...