Histone deacetylase (HDAC) 1 regulates chromatin compaction and gene expression by removing acetyl groups from lysine residues within histones. HDAC1 affects a variety of processes including proliferation, development, metabolism, and cancer. Reduction or inhibition of Rpd3, yeast and fly HDAC1 orthologue, extends longevity. However, the mechanism of rpd3's effects on longevity remains unclear....

Multiple pressures are today propelling the private sector towards greater incorporation of sustainability in firms’ business models and strategies: actions and innovations that demonstrate committed corporate social responsibility (CSR). Achieving success with CSR is often a long-term process, taking years to fully develop, institute and pay off financially. Yet most current research is based ...

Introduction. Cow longevity is one of the most economically important traits in the beef cow. Longevity is inter-related to other important traits, and, therefore, it is difficult to separate the importance of longevity, itself, from the importance of traits that are related to longevity. For example, reproductive performance is usually part of the culling criteria. It is often stated that repr...

The natural variation in leaf and plant longevity in Arabidopsis thaliana was analysed in a set of 45 ecotypes and 155 recombinant inbred lines derived from a Cape Verde Islands (Cvi) x Landsberg erecta (Ler) cross. Post-bolting longevity was inversely related to time to flowering and rosette leaf number in the set of 45 ecotypes, with Cvi having the longest and Ler the shortest post-bolting lo...

Are there limits to human longevity? We suggest a new demographic model to describe human demographic trajectories. Specifically, the model mathematically defines the limits of longevity. Through the demographic analysis of trends for Sweden (between 1751 and 2002), Switzerland (between 1876 and 2002) and Japan (between 1950 and 1999), which are the longest-lived countries, we would like to dem...

Mutations that increase the longevity of the soil nematode Caenorhabditis elegans could define genes involved in a process specific for aging. Alternatively, these mutations could reduce animal metabolic rate and increase longevity as a consequence. In ectotherms, longevity is often negatively correlated with metabolic rate. Consistent with these observations, environmental conditions that redu...

The life span of C. elegans can be increased via reduced function of the mitochondria; however, the extent to which mitochondrial alteration in a single, distinct tissue may influence aging in the whole organism remains unknown. We addressed this question by asking whether manipulations to ETC function can modulate aging in a cell-non-autonomous fashion. We report that the alteration of mitocho...

Family studies of exceptional longevity can potentially identify genetic and other factors contributing to long life and healthy aging. Although such studies seek families that are exceptionally long lived, they also need living members who can provide DNA and phenotype information. On the basis of these considerations, the authors developed a metric to rank families for selection into a family...

Although theories in both evolutionary biology and economics predict that an individual's health should be associated with the individual's time preference, no prior study has been done to empirically support or refute such predictions. By collecting detailed measures of health, time preference, and expected longevity on a sample of individuals in townships around Durban, South Africa, this stu...