Loperamide is a peripheral opiate agonist that can cause apoptosis and G2/M arrest in human cancer cell lines and may sensitize cells to chemotherapy. The objectives of this study were to investigate the effects of loperamide on viability, apoptosis and cell cycle kinetics in canine cancer cells and to establish whether the drug sensitizes cells to doxorubicin. Cell viability was assessed using...

Acute diarrhoea in expatriates in Bangladesh SIR,-The study by Van Loon et al (Gut 1989; 30: 492-5) illustrates an important aspect of management of adult acute diarrhoea in expatriates in Bangladesh. We have completed a larger study of loperamide and dioralyte in the treatment of acute adult diarrhoea in servicemen in shore bases and ships visiting foreign ports. Criteria for diarrhoea were tw...

pycnocycla spinosa decne. ex boiss. var. spinosa (fam. umbelliferae) is an essential oil-containing wild plant growing in central part of iran. hydroalcoholic extract of pycnocycla spinosa has antispasmodic and antidiarrheal activity. the aim of this study was to further investigate antidiarrheal and small intestinal transit effect of p. spinosa extract for a comparison with loperamide and dicy...

AIMS Many websites provide a means for individuals to share their experiences and knowledge about different drugs. Such User-Generated Content (UGC) can be a rich data source to study emerging drug use practices and trends. This study examined UGC on extra-medical use of loperamide among illicit opioid users. METHODS A website that allows for the free discussion of illicit drugs and is access...

Loperamide is a well-established antidiarrhoeal agent with effects on gastrointestinal motility. We have now shown that the drug influences ion transport. In isolated rabbit ileal mucosa loperamide caused a dose-related fall in potential difference and short-circuit current and reduced the serosa to mucosa flux of chloride. The electrical effects were inhibited by naloxone (10(-6)M) suggesting ...

The effect of loperamide and naloxone on mouth-to-caecum transit time was evaluated by the lactulose hydrogen breath test in four men and four women. Each subject underwent tests during the administration of placebo, loperamide (12-16 mg po), naloxone (40 micrograms/kg/h by a three-hour intravenous infusion), and loperamide plus naloxone, carried out at intervals of one or two weeks. The transi...

The Letter uncovers an issue which is increasingly relevant in Community Hospital practice. The authors have highlighted the following points with an interesting case and adequate referencing, but the points are relatively well reported and not novel. There has been a clearly documented increase in the number of reported cases of loperamide abuse and toxicity in the literature in recent years. ...

BACKGROUND Diarrhea is one of the most disturbing effects of chemotherapy, affecting quality of life on the one hand and limiting applicable doses on the other. Irinotecan (CPT-11) and 5-fluorouracil (5-FU) are associated with an elevated risk of developing severe diarrhea. Standard therapy consists of high-dose loperamide, but is associated with frequent failure. Other therapeutic regimens are...

Wood creosote, the principal ingredient in Seirogan, has a long history as a known gastrointestinal microbicidal agent. When administered orally, the intraluminal concentration of wood creosote is not sufficiently high to achieve this microbicidal effect. Through further animal tests, we have shown that antimotility and antisecretory actions are the principal antidiarrheal effects of wood creos...

Objective: The objective of this selective EBM review is to determine which treatment is more effective between loperamide and racecadotril to treat acute diarrhea in adults. Study design: Review of three English language primary randomized controlled studies published from 1999-2005. Data Sources: First study was a RCT that was double blinded, double placebo, parallel study group and second an...