OBJECTIVE To observe the clinical effect of escin on patients with cutaneous pruritus caused by blood stasis and wind-dryness and to prove the theory that "wind should be treated by regulating blood disorder, and wind disappears after activating blood" in traditional Chinese medicine (TCM). METHODS Fifty-one patients were randomly divided into escin-treated group (n=30) and loratadine-treated...

BACKGROUND Loratadine is a long-acting tricyclic antihistamine with selective peripheral histamine H(1)-receptor antagonist activity. Loratadine 10-mg tablets have been reported to be rapidly absorbed after once-daily administration for 10 days in healthy adult subjects, with a T(max) of 1.3 hours for loratadine and 2.5 hours for its major active metabolite, descarboethoxyloratadine. The t(1/2)...

Purpose: To developing a simple, rapid and reliable analytical method for loratadine based on charge transfer complexation with chloranilic acid. Methods: The complex between loratadine and the complexing agent, chloranilic acid, was formed by mixing appropriate volumes of their solutions in non-aqueous media. Some features of the formed complex, such as molar ratio of the reaction and effect o...

Loratadine is an efficacious, non-drowsy antihistaminic molecule prescribed for allergic skin. The conventional oral dosage form associated with various side effects, limited and variable absorption. present study attempts to improve the effectiveness of drug by formulating a niosome loaded hydrogel loratadine treating Ether injection method was used prepare niosomes using Box Behnken design. P...

Background: Loratadine is a commonly used selective non‐sedating antihistaminic drug. Desloratadine is the active metabolite of loratadine and, in addition, a potential impurity in loratadine bulk powder stated by the United States Pharmacopeia as a related substance of loratadine. Published methods for the determination of both analytes suffer from limited throughput due to the time‐consuming ...

Many drugs can cause unexpected muscle disorders, often necessitating the cessation of an effective medication. Inhibition of monocarboxylate transporters (MCTs) may potentially lead to perturbation of l-lactic acid homeostasis and muscular toxicity. Previous studies have shown that statins and loratadine have the potential to inhibit l-lactic acid efflux by MCTs (MCT1 and 4). The main objectiv...

A single blind, placebo-controlled, parallel-group study was performed during a pollen season in 41 patients suffering from seasonal allergic rhinitis. A group of 26 patients was treated with loratadine (10 mg daily in one dose) for 3 weeks. Placebo was given in the group of 15 patients (1 tablet daily) during 8-10 days. The following parameters were assessed: clinical symptoms (rhinorhea, snee...

To examine the risk of hypospadias after exposure to loratadine and other antihistamines during pregnancy, we conducted a population-based case-control study in four Danish counties, which account for 30% of the Danish population (approximately 1.6 M). We obtained data on maternal use of antihistamines from prescription databases, and data on birth outcomes from the Danish Medical Birth Registr...

BACKGROUND In 2006, the Norwegian Medicines Agency mandated a switch from desloratadine, ebastine, or fexofenadine to cetirizine or loratadine in patients with allergic rhinitis (AR) or chronic urticaria (CU). In an online survey, patients whose medication was switched assessed the impact on efficacy, fatigue, and work productivity/attendance. METHODS Allergy patients in Norway completed a 25...

Objective: To observe the clinical efficacy and safety of desloratadine citrate disodium in the treatment of allergic rhinitis (AR). Methods: 200 patients with AR treated at otorhinolaryngology department of Sichuan Provincial People’s Hospital from January, 2012 to October, 2014 were selected for this study. They were randomly divided into therapeutic group and control group with 100 patients ...