Po-Ru Loh, ∗ Ardavan F. Oskooi, Mihai Ibanescu, Maksim Skorobogatiy, and Steven G. Johnson Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139 Center for Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 OmniGuide Communications, One Kendall Square, Building 100 No. 3, Cambridge MA 02139 Génie Physique, École Polytech...

Affiliations of authors: Internal Medicine and Pharmacology, University of Michigan Medical School, Ann Arbor, MI (JMR); Edith Sanford Breast Cancer Research, Sanford Health and Research, Sioux Falls, SD (BLJ); Department of Medicine, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA (MR); Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX...

Increasing genomic instability is associated with aging in eukaryotes, but the connection between genomic instability and natural variation in life span is unknown. We have quantified chronological life span and loss-of-heterozygosity (LOH) in 11 natural isolates of Saccharomyces cerevisiae. We show that genomic instability increases and mitotic asymmetry breaks down during chronological aging....

Comparisons of two lognormal population means are investigated. For large samples, the conventional test for significance of the population means is the ordinary Student /-test with normal critical value. By Chen and Loh's result (Ann. Statist. 20 (1992)), however, the transformed i-test based on legdata is asymptotically more powerful than the ordinary i-test. In this paper, a new power transf...

Objective(s): Variation in microsatellite sequences that are dispersed in the genome has been linked to a deficiency in cellular mismatch repair system and defects in several genes of this system are involved in carcinogenesis. Our aim in this study was to illustrate microsatellite DNA alteration in esophageal cancer. Materials and Methods: DNA was extracted from formalin fixed paraffin embedde...

Recent evidence indicates that the mutation of retinoblastoma suscep tibility (RB) gene is also involved in the development of osteosarcoma. We studied 30 cases of osteosarcoma for the structural anomalies of the RB gene by Southern hybridization analysis with cDNA probes of the RB gene. Thirteen cases (43%) showed structural anomalies of the RB gene. They included the total or partial deletion...

Recent evidence indicates that the mutation of retinoblastoma susceptibility (RB) gene is also involved in the development of osteosarcoma. We studied 30 cases of osteosarcoma for the structural anomalies of the RB gene by Southern hybridization analysis with cDNA probes of the RB gene. Thirteen cases (43%) showed structural anomalies of the RB gene. They included the total or partial deletion,...