نتایج جستجو برای: low bioavailable drug
تعداد نتایج: 1728796 فیلتر نتایج به سال:
COVID-19 caused by SARS-CoV-2 is a serious health crisis worldwide and requires safe efficacious treatment to combat the disease. RNA-dependent RNA polymerase (RdRp) main protease (Mpro) are vital enzymes in life cycle considered effective drug targets. In current investigation, fourteen (14) flavonoids from honey were assessed analyze their potential for RdRp Mpro inhibition using computationa...
The structural complexity of many natural products sets them apart from common synthetic drugs, allowing them to access a biological target space that lies beyond the enzyme active sites and receptors targeted by conventional small molecule drugs. Naturally occurring cyclic peptides, in particular, exhibit a wide variety of unusual and potent biological activities. Many of these compounds penet...
Inhibitors of checkpoint kinase 1 (CHK1) are of current interest as potential antitumor agents, but the most advanced inhibitor series reported to date are not orally bioavailable. A novel series of potent and orally bioavailable 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitrile CHK1 inhibitors was generated by hybridization of two lead scaffolds derived from fragment-based drug design...
•Plot of sample P richness vs. Bioavailable particulate P (PP). •Slope suggests from that PP is 35% bioavailable • This is not always the case two point were not included in the regression Bioavailable P Contributions •Results of all assays are presented in the table. •If the fraction of bioavailable P (fbio) is known then the contributions of each P form can change dramatically. •Contributions...
This article provides a perspective on the current status of drug therapy for invasive fungal diseases, together with priorities for the future development of novel compounds. Key opportunities for new drugs include production of orally bioavailable agents for the treatment of invasive aspergillosis, invasive candidiasis, cryptococcal meningitis and mucosal and urinary Candida infections. Orall...
Lithium is the most effective mood stabilizer for the treatment of bipolar disorder, but it is toxic at only twice the therapeutic dosage and has many undesirable side effects. It is likely that a small molecule could be found with lithium-like efficacy but without toxicity through target-based drug discovery; however, therapeutic target of lithium remains equivocal. Inositol monophosphatase is...
Pleconaril (VP 63843) is a novel orally bioavailable small molecule with broad antipicornavirus (enterovirus and rhinovirus) activity. Ten independently derived pleconaril-resistant variants of coxsackievirus B3 were isolated from cell culture. The molecular basis of drug resistance and the biologic properties of the drug-resistant viruses were investigated. RNA sequence analysis revealed amino...
Understanding how plant functional traits shape nutrient limitation and cycling on land is a major challenge in ecology. This is especially true for lowland forest ecosystems of the tropics which can be taxonomically and functionally diverse and rich in bioavailable nitrogen (N). In many tropical regions, however, diverse forests occur side-by-side with monodominant forest (one species >60% of ...
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