Recent results have identified a family of Lsm (Like Sm) proteins that are related to the Sm protein family. Seven Lsm proteins form a complex, which interacts with the U6 snRNA and functions in splicing. In addition, a different complex of Lsm proteins interacts with cytoplasmic mRNA and promotes its turnover. These diverse functions of Lsm proteins suggest that they are important modulators o...

OBJECTIVE To investigate the frequency and determinants of liver stiffness measurement (LSM) failure by means of FibroScan in "real-life" Chinese patients. METHODS A total of 38,464 "real-life" Chinese patients in 302 military hospital of China through the whole year of 2013, including asymptomatic carrier, chronic hepatitis B, chronic hepatitis C, liver cirrhosis (LC), alcoholic liver diseas...

Nitric oxide (NO) relaxes most smooth muscle, including the circular smooth muscle (CSM) of the esophagus, whereas in the adjacent longitudinal smooth muscle (LSM), it causes contraction. The second messenger pathways responsible for this NO-induced LSM contraction are unclear, given that these opposing effects of NO are both cGMP dependent. In intestinal LSM, but not CSM, cADP ribose (cADPR)-d...

Least squares migration (LSM) is applied to synthetic data with the purpose of removing the ”acquisition footprint” noise from migrated sections. Results for simple point scatterer and meandering stream channel models suggest that LSM can significantly attenuate the acquisition footprint noise. For comparison, the corresponding Kirchhoff migrated sections show noticeable artifacts due to a coar...

BACKGROUND Few studies have investigated predictors of discordance between liver biopsy (LB) and liver stiffness measurement (LSM) using FibroScan®. We assessed predictors of discordance between LB and LSM in chronic hepatitis B (CHB) and investigated the effects of necroinflammatory activity. METHODS In total, 150 patients (107 men, 43 women) were prospectively enrolled. Only LSM with ≥ 10 v...

BACKGROUND Liver stiffness measurement (LSM) using transient elastography (FibroScan®) can assess liver fibrosis noninvasively. This study investigated whether LSM can predict the development of liver-related events (LREs) in chronic hepatitis B (CHB) patients showing histologically advanced liver fibrosis. METHODS Between March 2006 and April 2010, 128 CHB patients with who underwent LSM and...

This work presents a novel least squares matrix algorithm (LSM) for the analysis of rapidly changing systems using state-space modelling. The LSM algorithm is based on the Hankel structured data matrix representation. The state transition matrix is updated without the use of any forgetting function. This yields a robust estimation of model parameters in the presence of noise. The computational ...

An analytical equation is derived for total triple phase boundary length per unit volume (LTPB) in an isotropic uniform random microstructure of LSM/YSZ composite cathode. The equation is applicable to YSZ and LSM particles of any convex shapes and size distributions. The equation explicitly relates LTPB to the shapes, mean sizes, coefficient of variation (a measure of the spread in a size dist...

Both migration deconvolution (MD) and least squares migration (LSM) are capable of improving the resolution and suppress acquisition footprints in migrated images. In this report, I investigate the relative performance of these two methods in enhancing migration image quality, suppressing artifacts and computational efficiency. Both MD and LSM were implemented on synthetic data generated from p...

Digital quantification of a two-dimensional structure was applied to a GDC(Gd₂O₃-doped CeO₂)/LSM(La₀.₈₅Sr₀.₁₅MnO₃) composite cathode employed for solid oxide fuel cells. With the aid of high-resolution imaging capability based on secondary and backscattered electron images, two-dimensional electron micrographs were converted to digital binary files using an image processing tool combined with t...