Nusinersen (ISIS-SMNRx or ISIS 396443) is an antisense oligonucleotide drug administered intrathecally to treat spinal muscular atrophy. We summarize lumbar puncture experience in children with spinal muscular atrophy during a phase 1 open-label study of nusinersen and its extension. During the studies, 73 lumbar punctures were performed in 28 patients 2 to 14 years of age with type 2/3 spinal ...

OBJECTIVE To see whether the incidence of cerebral herniation is increased immediately after lumbar puncture in children with bacterial meningitis and whether any children with herniation have normal results on cranial computed tomography. DESIGN Retrospective review of case notes; computed tomograms were read again. SETTING Large paediatric teaching hospital. SUBJECTS 445 children over 3...

BACKGROUND Lumbar puncture is often used for the diagnosis and treatment of subarchnoid hemorrhage, infection of Cerebro-spinal Fluid (CSF), hydrocephalus in neurosurgery department patients. It is general that paradoxical herniation followed by lumbar puncture is quite rare in decompressive craniectomy cases; the related reports are very few. Moreover, most of the paradoxical herniation cases ...

PURPOSE To examine the hypothesis that lumbar puncture alone may cause meningeal enhancement in the brain. METHODS We prospectively reviewed the brain MR examinations of all patients from a 6-month period who were studied within 1 month after lumbar puncture. We also retrospectively reviewed all cases of dural-arachnoidal enhancement in the brain from the preceding 18-month period. RESULTS ...

Correction Following the publication of our article [1] an error in the case presentation section was noted. In the description of the lumbar puncture procedure, we incorrectly stated the units of the opening pressure. Upon lumbar puncture, performed in the lateral decubitus position, an opening pressure of 40 mm of water was documented. Should read: Upon lumbar puncture, performed in the later...

A 29-year-old woman presented with dilated epidural veins and incapacitating headache after undergoing a lumbar puncture. Two months later, the results of follow-up MR imaging were normal. These findings suggest that temporary dilation of the epidural vein may occur in association with post-lumbar puncture intracranial hypotension syndrome. In these cases, it seems useful to confirm whether the...

Medical notes of 123 patients with subarachnoid haemorrhage were examined. No patient deteriorated at the time of lumbar puncture. All but 2 patients with associated intracerebral haematomas had markedly impaired consciousness or focal signs. Two of 30 patients with meningitis were initially diagnosed as subarachnoid haemorrhage, and one died without lumbar puncture. If consciousness is not mar...

The place of computed tomography and lumbar puncture in suspected bacterial meningitis EDITOR,-We should like to respond to the recently published annotation on the place of computed tomography and lumbar puncture in suspected bacterial meningitis.' The table of contraindications to lumbar puncture in the child with suspected acute bacterial meningitis is welcome and we would agree that lumbar ...

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Post-lumbar puncture headache is the most common complication of lumbar puncture. This condition is thought to be the result of persistent cerebrospinal fluid leakage at the puncture site, leading to low cerebrospinal fluid pressure and traction on the meninges and intracranial veins. Associated symptoms may include nausea, vomiting, auditory and vestibular symptoms. Meningeal irritation signs ...