BACKGROUND The shortage of donor hearts has made use of non-beating hearts as cardiac grafts an attractive possibility for heart transplant candidates. The purpose of this study was to evaluate the utility of leukocyte-depleted hot shot cardioplegia for resuscitation of non-beating hearts obtained from asphyxiated dogs via an autoperfusing heart-lung circuit. METHODS Mongrel dogs were divided...

BACKGROUND Pulmonary edema is a hallmark of acute respiratory distress syndrome (ARDS). Smoke inhalation causes ARDS, thus significantly increasing the mortality of burn patients. Adipose-derived stem cells (ASCs) exert potent anti-inflammatory properties. The goal of the present study was to test the safety and ecfficacy of ASCs, in a well-characterized clinically relevant ovine model of ARDS....

Water transport across epithelial and endothelial barriers in bronchopulmonary tissues occurs during airway hydration, alveolar fluid transport, and submucosal gland secretion. Many of the tissues involved in these processes are highly water permeable and express aquaporin (AQP) water channels. AQP1 is expressed in microvascular endothelia throughout the lung and airways, AQP3 in epithelia in l...

1 mg ovine prolactin was injected intramuscularly into rabbit fetuses (24th day of gestation) located in one of the two uterine horns exposed by laparotomy (n = 12). Fetuses in the other uterine horn were injected with an identical volume of vector and served as controls (n = 13). 2 days later the fetuses were removed by a second laparotomy and sacrificed. Analysis of lung tissue composition yi...

We have investigated the mechanism of TOP-53 distribution to the lung and lung-localized tumor. In contrast to etoposide (VP-16), TOP-53 contains a basic aminoalkyl group that may predispose it to interact specifically with phospholipids, consequently leading to an increase of drug accumulation in the tissues. Therefore, we have studied its interaction with phospholipids in vitro using an organ...

Objective. Lipid peroxidation plays a critical role in burn-induced plasma leakage, and ulinastatin has been reported to reduce lipid peroxidation in various models. This study aims to examine whether ulinastatin reduces fluid requirements through inhibition of lipid peroxidation in a swine burn model. Methods. Forty miniature swine were subjected to 40% TBSA burns and were randomly allocated t...

This study was designed in order to evaluate the influence of advanced age on extravascular lung water (EVLW) content. Forty patients undergoing aortocoronary bypass grafting were prospectively divided into two groups according to age below 45 years (group 1; n = 20) and above 65 years (group 2; n = 20). The EVLW was measured using the double indicator dilution technique with indocyanine green ...

lung contusion is an entity involving injury to the alveolar capillaries, without any tear or cut in the lung tissue. this results in accumulation of blood and other fluids within the lung tissue. the excess fluid interferes with gas exchange leading to hypoxia. the pathophysiology of lung contusion includes ventilation/perfusion mismatching, increased intrapulmonary shunting, increased lung wa...

terminal drought stress during grain filling period has recently become more common in the semiarid mediterranean regions, where wheat (triticum aestivum) is grown as an important winter cereal crop. the objective of this experiment was to study the effect of terminal drought stress on grain yield, gas exchange variables, and some physiological traits of nine bread wheat cultivars. an experimen...