BACKGROUND & OBJECTIVES The prerequisite of radioimmunotherapy is stable binding of a radionuclide to monoclonal antibodies, which are specific to the tumour-associated antigen. Most B-cell lymphomas express CD20 antigen on the surface of the tumour cells, making it a suitable target for therapeutic radioactive monoclonal antibodies. In the present study, the immunoconjugate of biosimilar Ritux...

Objective(s): In this work a new possible agent for radiosynovectomy has been targeted for articular pain palliation. Materials and Methods: Lu-177 of 2.6-3 GBq/mg specific activity was obtained by irradiation of natural Lu2O3 sample with thermal neutron flux of 4 × 1013 n.cm-2.s-1. The product was converted into chloride form which was further used for labeling of 177Lu-phytate complex and che...

Bleomycins are tumor seeking antibiotics that are widely used in cancer chemotherapy (Fig. 1). It is believed that bleomycin antibiotics interfere with DNA as false nucleotides, assuming the dithiazole moiety acts like a purine base [20]. It has been shown that labeling of bleomycin with bi/trivalent radioisotopes can produce pharmacologically active compounds carrying a diagnostic and/or thera...

Lu ıs Carletto, Adam Troncoso, Ana C Rocha, Zolt an Rumbus, Margit Solym ar, and Andr as Garami* Department of Pathophysiology and Gerontology; Medical School, University of P ecs; P ecs, Hungary; Medical School; Federal University of Paran a; Curitiba, Brazil; Medical School; Federal University of S~ao Francisco Valley Foundation; Petrolina, Brazil; Medical School; Federal University of Alagoa...

1. Jaffe AS, Apple FS. High-sensitivity cardiac troponin: hype, help, and reality. Clin Chem 2010;56:342–4. 2. Keller T, Zeller T, Peetz D, Tzikas S, Roth A, Czyz E, et al. Sensitive troponin I assay in early diagnosis of acute myocardial infarction. N Engl J Med 2009;361:868–77. 3. Reichlin T, Hochholzer W, Bassetti S, Steuer S, Stelzig C, Hartwiger S, et al. Early diagnosis of myocardial infa...

A novel chimeric protein-based HIV-1 fusion inhibitor targeting gp41 with high potency and stability Chungen Pan, Lifeng Cai, Hong Lu, Lu Lu, and Shibo Jiang* From Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065 MOE/MOH Key Laboratory of Medical Molecular Virology and Institute of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032,...

Masanao Miwa, Satoshi Honjo, Petcharin Srivatanakul, Lu Zeng, Akihiro Ueda, Chuanxu Jao, Emi Ohta, Takahiro Fujii, Banchob Sripa, Adisorn Jedpiyawongse, Somyos Deerasamee, Mantana Matharit, Chutiwan Viwatthanasittiphong, Dhiraphol Chenvidhya, Masanao Miwa Bioscience, Nagahama Institute of Bio-Science and Technology, Japan, Fukuoka Hospital, National Hospital Organization, Japan, National Cancer...

Lei Wu ( ),1,* Lu Li,2 Jie-Fang Zhang,1 Dumitru Mihalache,3 Boris A. Malomed,4 and W. M. Liu5 1Institute of Nonlinear Physics, Zhejiang Normal University, Jinhua, Zhejiang 321004, China 2Institute of Theoretical Physics, Shanxi University, Taiyuan, Shanxi 030006, China 3Horia Hulubei National Institute for Physics and Nuclear Engineering, R-077125 Magurele-Bucharest, Romania 4Department of Phys...

The purpose of this note is to complement part of a theorem from the remarkable paper of Fontaine and Mazur on geometric Galois representations [5]. Fix a prime p, and let K be a finite extension of the p-adic numbers Qp. Fix an algebraic closure K̄ of K and let G be the Galois group of K̄ over K. Fontaine’s theory [3] classifies various types of representations ρ : G→Aut(V) on finite-dimensional...