Abstract Nonimmune fetal hydrops (NIFH) has underlying diverse etiology with generalized lymphatic dysplasia being one such cause. Lymphatic malformation-6 is a type of that due to homozygous or compound heterozygous variants in the PIEZO1 gene. The clinical features associated this condition during life are nonimmune manifests widespread edema, other systemic manifestations like pericardial/pl...

Here we report successful thoracoscopic-assisted sclerotherapy of a large, prenatally diagnosed microcystic thoracoabdominal lymphatic malformation in a 3-month-old infant born at 38 weeks gestational age. Compression of the inferior vena cava and aortic displacement was demonstrated on imaging. Treatment options include medical management, percutaneous sclerotherapy, or surgical resection. The...

In this case report, we discuss the presentation, physical examination, imaging studies, and diagnosis of a rare vascular lymphatic malformation in upper limb 3-year old child. Vascular malformations are uncommon conditions, which can be misidentified as malignant tumours children at first glance. The image study is essential to identify them decide best treatment strategy each situation.

Sclerotherapy and surgery are both effective treatment methods for lymphatic malformations.1,2 However, recurrence due to incomplete resection is a common problem, often necessitating multiple treatment sessions.2 Intralesional endoscopy has been described as a diagnostic approach and potential therapeutic tool.1,3 We report a case of a 12-year-old male patient who presented with a mainly subcu...

We report a case of necrotizing fasciitis with an accompanying toxic shock syndrome caused by Group G Streptococcus in a pediatric patient with a lymphatic malformation. Pediatricians need to be aware of the possibility of such infections, especially in those with vascular/lymphatic malformations, as early treatment is critical for survival.

Lymphatic malformations (LMs) are vascular anomalies thought to arise from dysregulated lymphangiogenesis. These lesions impose a significant burden of disease on affected individuals. LM pathobiology is poorly understood, hindering the development of effective treatments. In the present studies, immunostaining of LM tissues revealed that endothelial cells lining aberrant lymphatic vessels and ...

INTRODUCTION Mesenteric lymphatic malformations are rare, benign tumors that are most commonly found in children. The presentation of these tumors is variable and may either be innocuous or life threatening. It has been suggested that mesenteric lymphatic malformations are congenital; however, there is evidence that their growth may be stimulated by local trauma. CASE PRESENTATION We describe...

American cooperative group in 1972, the Intergroup Rhabdomyosarcoma Study Group has undertaken a series of clinical trials that have employed chemotherapy, surgery, and irradiation for local control. The addition of systemic chemotherapy has markedly improved long-term survival in affected children. These children now have an excellent prognosis with current multimodality therapy. A recent revi...