The discovery of the lymphatic system has a long and fascinating history. The interest in anatomy and physiology of this system paralleled that of the blood cardiocirculatory system and has been maybe obscured by the latter. Paradoxically, if the closed blood system appeared open in Galen's anatomy and physiology, and took a very long time to be correctly described in terms of pulmonary and gen...

Blood and lymphatic vessels develop in a parallel, but independent manner, and together form the circulatory system allowing the passage of fluid and delivering molecules within the body. Although the lymphatic vessels were discovered 300 years ago, at the same time as the blood circulation was described, the lymphatic system has remained relatively neglected until the present. This is in part ...

The lymphatic system comprises a network of interconnected and blind-ended vessels whose central function is to maintain fluid homeostasis. Similar to the vessels of the circulatory system, the lymphatic system consists of a hierarchical network of small and large caliber vessels, which function together to allow fluid drainage. Lymphatic capillaries are lined by endothelial cells that are high...

Animal models of diseases, particularly mice, are considered to be the cornerstone for translational research in immunology. The aim present study is model geometry and analyze network structure murine lymphatic system (LS). algorithm building graph LS makes use anatomical data. To identify edge directions model, a mass balance approach lymph dynamics based on Hagen–Poiseuille equation applied....