After activation, populations of antigen-specific T cells flow between sites of antigen expression, local lymphoid structures and other lymphoid and non-lymphoid organs. In this study, we documented the in vivo dynamics of a CD8(+) T cell response to antigen delivered using herpes simplex virus amplicon vectors and revealed several unexpected features. First, the T cells localized to the site o...

Lymphoid tissue is found all over the body. It occurs in wellorganized lymphoid organs, such as the lymph nodes and the spleen, or as extranodal lymphoid tissue as part of the gut, skin, and lung. It may develop in any part of the body under specific conditions. The lymphoid organs are divided into central and peripheral organs. The bone marrow and the thymus constitute the central lymphoid org...

Infiltration and proliferation of Theileria parva infected lymphocytes in bovine host lymphoid organs is one of the hallmarks of T. parva infection. The relative abundance of parasites within infected host tissues, both lymphoid and non-lymphoid is however unknown. Using quantitative PCR, we have shown that significantly higher concentrations of T. parva DNA are detected in the spleens of cattl...