نتایج جستجو برای: lyophilized formulation
تعداد نتایج: 113809 فیلتر نتایج به سال:
Taxol is a marketed product for the treatment of ovarian, breast, non-small cell lung cancer and AIDS-related Kaposi's Sarcoma. It is thus far one of the most effective anticancer drugs available on the market. However, paclitaxel is only sparingly soluble in water and therefore, intravenous administration depends on the use of the non-ionic surfactant Cremophor EL (polyethoxylated castor oil) ...
Abstract: Background: Paliperidone is indicated for the treatment of schizophrenia. It has an absolute oral bioavailability about 28% as it poorly soluble in water and also undergoes hepatic first-pass metabolism. Objectives: The purpose present study to improve solubility, vitro paliperidone by formulating nanostructured lipid carrier (NLC). Materials Methods: High shear homogenization followe...
A trivalent influenza split vaccine was formulated at high concentration for coating on the transdermal microneedle system. Monovalent bulks of three strains, two and one B strain were diafiltrated, concentrated, lyophilized. The lyophilized powder each separately reconstituted subsequently combined into a formulation vaccine. process converted monovalent with low hemagglutinin (HA) concentrati...
Abstract: Background: Cinacalcet Hydrochloride (CINH) is a BCS class IV drug. It mainly used for the treatment of chronic renal disease and parathyroid cancer. exhibits poor oral bioavailability less than 25%. The main objective to improve stability CINH by formulating lyophilized Nanostructure Lipid Carrier (NLC) into tablet dosage form. Materials Methods: In this research, Glycerylmonostearat...
BACKGROUND A large gap for the support of point-of-care testing is the availability of reagents to support quality control (QC) of diagnostic assays along the supply chain from the manufacturer to the end user. While reagents and systems exist to support QC of laboratory screening tests for glucose-6-phosphate dehydrogenase (G6PD) deficiency, they are not configured appropriately to support poi...
Background: The short life time of human platelet units has led to a chronic shortage of fresh platelets in blood transfusion centers. Many approaches have been investigated experimentally to produce new hemostatically active platelet products that are capable of long term storage. Infusible platelet membrane (IPM) prepared from fresh or outdated human platelets have been developed as an altern...
This study aimed to prepare the aminoclay-lipid hybrid composite to enhance the drug release and improve the oral bioavailability of poorly water-soluble fenofibrate. Antisolvent precipitation coupled with an immediate freeze-drying method was adopted to incorporate fenofibrate into aminoclay-lipid hybrid composite (ALC). The optimal composition of the ALC formulation was determined as the rati...
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