background the ability to follow the distribution and migration of biologically active cells in human is essential for the development of cell-based therapies and diagnostics. nuclear medicine imaging is widely applied in clinic as an attractive technique for in vivo wbc and stem cell tracking. the aim of this study was to evaluate prosthesis infection of a 51 years old man with previous histor...

and The National Graduate School for Biomaterials and Tissue Engineering ACADEMIC DISSERTATION To be publicly discussed with the permission of the Medical Faculty of the University of Helsinki, in the large lecture hall (Iso luentosali) Work hard and try your best! If you then fail I am not angry.-my father-This thesis is based on the following original publications. They are referred to in the...

Although the real actual incidence of metallosis is unknown, it is described as a rare diagnosis with a 5% estimated incidence in the hip prosthetic replacements. The adoption of non-metallic articular prosthetic devices, made of polyethylene and ceramic, is the main reason to the diminishing number of reported cases. We present a case of metallosis with a clinical systemic presentation in a pa...

We describe six patients with aggressive granulomatous lesions around cementless total hip prostheses. Two patients previously had a cemented prosthesis in the same hip. The Lord prosthesis was used in five patients, the PCA in one. Both prostheses were made of chrome-cobalt alloy. Pain on weight-bearing occurred on average 3.2 years after the cementless arthroplasty, and at that time radiograp...

The hip joint is a strongly loaded joint and highly vulnerable to any diseases and pathological changes related to loading conditions (Wall, 2002). Improper load distribution in the hip joint leads to its pathological changes that consist in anomalous growth of the acetabulum and femur. In the most drastic clinical cases the only way of treatment is to replace the natural degenerated joint with...

The natural distribution of stress in the femur is altered when total hip arthroplasty (THA) performed. In fact, a stem inserted inside femur, there variation due to difference rigidity between material with which made and femur. This generates phenomenon shielding. aim this study design an optimized prosthesis that guarantees excellent rotational stability reduced Methods: Through finite eleme...

Background The ability to follow the distribution and migration of biologically active cells in human is essential for the development of cell-based therapies and diagnostics. Nuclear medicine imaging is widely applied in clinic as an attractive technique for in vivo WBC and stem cell tracking. The aim of this study was to evaluate prosthesis infection of a 51 years old man with previous histo...

The surface finish of a femoral stem plays an important role in the longevity of cemented total hip arthroplasty. In efforts to decrease the rate of aseptic loosening, some prostheses have been designed to have a roughened surface that enhances bonding between the prosthesis and cement, but clinical outcomes remain controversial. We present a rare case of massive osteolysis with extreme femoral...

In patients suffering of osteoarthritis of the hip (a degenerative condition of the hip that finally leads to anatomical and functional impairment of the joint), the only efficient treatment in advanced stages of the disease is the surgical replacement of the joint with a total hip prosthesis. Unfortunately, despite improving the composition of the materials from which these prostheses are made...

We studied the rates of revision for 53,698 primary total hip replacements (THRs) in nine different groups of disease. Factors which have previously been shown to be associated with increased risk of revision, such as male gender, young age, or certain types of uncemented prosthesis, showed important differences between the diagnostic groups. Without adjustment for these factors we observed an ...