From the Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences & Research, Bangalore, India. Manuscript received September 27, 2012; accepted October 2, 2012. A19-year-old male with cyanosis and clubbing was diagnosed with tetralogy of Fallot (TOF). Chest x-ray (A) showed prominent rib notching involving the left hemithorax (arrow). Major aortopulmonary collaterals (arrows...

p i J a To the Editor: The transition from the QRS complex to the ST-segment on the 12-lead electrocardiogram (ECG) has been conventionally termed the ST junction (STj). Occasionally, the terminal portion of the QRS complex manifests a notch or slur when transiting into the ST-segment. This has been described as a normal variant in healthy individuals (1) in whom STj is very often elevated. The...

One of the best-characterized lineage restrictions in developing vertebrates occurs between adjacent -rhombomeres of the hindbrain. It was recently shown that cells at the boundaries of zebrafish rhombomeres also differ from non-boundary cells in their migratory abilities, a difference driven by Notch signaling.

The increased incidence of high-frequency components (notching) in electrocardiographic (ECG) recordings previously has been related to coronary artery disease, primary myocardial disease, and biventricular enlargement. This study included 130 subjects on whom autopsy permission was obtained, who had one or more sets of high-frequency, orthogonal ECG (XYZ) leads and directwriting standard ECG l...

Pre-eclampsia is a pregnancy complication characterized by hypertension and proteinuria. There are several factors associated with an increased risk of developing pre-eclampsia, one of which is increased uterine artery resistance, referred to as "notching". However, some women do not progress into pre-eclampsia whereas others may have a higher risk of doing so. The placenta, central in pre-ecla...

Anterior femoral notching during total knee arthroplasty is a potential risk factor for periprosthetic supracondylar femur fracture. We conducted a study to determine if the design of the femoral implant changes the risk for periprosthetic supracondylar femur fractures after anterior cortical notching. An anterior cortical defect was created in 12 femoral polyurethane models. Six femora were in...

Letter by Hayashi et al Regarding Article, “Heritability of Early Repolarization: A Population-Based Study” To the Editor: We read with much interest the article published by Reinhard et al.1 The article described a high rate of heritability of early repolarization (ER) in a general population. Early repolarization was characterized by ECG morphological features of the QRS complex (ie, notching...

p i J a To the Editor: The transition from the QRS complex to the ST-segment on the 12-lead electrocardiogram (ECG) has been conventionally termed the ST junction (STj). Occasionally, the terminal portion of the QRS complex manifests a notch or slur when transiting into the ST-segment. This has been described as a normal variant in healthy individuals (1) in whom STj is very often elevated. The...