Inspired by microvesicle-mediated intercellular communication, we propose a hybrid vector for magnetic drug delivery. It consists of macrophage-derived microvesicles engineered to enclose different therapeutic agents together with iron oxide nanoparticles. Here, we investigated in vitro how magnetic nanoparticles may influence the vector effectiveness in terms of drug uptake and targeting. Huma...

As a fast developing alternative of traditional therapeutics, photodynamic therapy (PDT) is an effective, noninvasive, nontoxic therapeutics for cancer, senile macular degeneration, and so on. But the efficacy of PDT was compromised by insufficient selectivity and low solubility. In this study, novel multifunctional silica-based magnetic nanoparticles (SMNPs) were strategically designed and pre...

Recently, magnetic-based theranostic nanoparticle (MBTN) systems have been studied, researched, and applied extensively to detect and treat various diseases including cancer. Theranostic nanoparticles are advantageous in that the diagnosis and treatment of a disease can be performed in a single setting using combinational strategies of targeting, imaging, and/or therapy. Of these theranostic st...

Several species of Magnetotactic bacteria have been discovered recently. These bacteria synthesize intracellular magnetic nanoparticles in specific sizes and shapes and arrange them in chains. These particles called magnetosomes and can be used for drug-delivery, cell-targeting and hyperthermia. Magnetotactic bacteria navigate along the magnetic field; this process is known as ‘magnetotaxis’ wh...

Magnetic drug targeting is a drug delivery system applicable to cancer treatment. Coated magnetic particles, called carriers, are very useful for delivering chemotherapeutic drugs. In the present research, casein-coated iron oxide nanocarriers (CCIONPs) of core shell nanostructure have been described as being applicable to magnetic drug targeting. The structure, morphology, and composition of p...

abstractgene therapy is a therapeutic approach to deliver genetic material into cells to alter their function in entire organism. one promising form of gene delivery system (dds) is liposomes. the success of liposome-mediated gene delivery is a multifactorial issue and well-designed liposomal systems might lead to optimized gene transfection particularly in vivo. liposomal gene delivery systems...

Targeting specific sites in vivo for the delivery of therapeutic compounds presents a major obstacle to the treatment of many diseases. One targeted delivery technique that has gained prominence in recent years is the use of magnetic nanoparticles. In these systems, therapeutic compounds are attached to biocompatible magnetic nanoparticles and magnetic fields generated outside the body are focu...

Despite advances in controlled drug delivery, drug delivery systems (DDSs) with controlled activated drug release and high spatial and temporal resolution are still required. Theranostic nanomedicine is capable of diagnosis, therapy, and monitoring the delivery and distribution of drug molecules and has received growing interest. In this study, a near-infrared light-controlled "off-on" DDS with...

Thermosensitive liposomes are a promising tool for external targeting of drugs to solid tumors when used in combination with local hyperthermia or high intensity focused ultrasound. In vivo results have demonstrated strong evidence that external targeting is superior over passive targeting achieved by highly stable long-circulating drug formulations like PEGylated liposomal doxorubicin. Up to M...