A group of children aged 6-17 years was recruited and followed up for 12 months to study the impact of schistosome infection on malaria parasite prevalence, density, distribution and anemia. Levels of cytokines, malaria specific antibodies in plasma and parasite growth inhibition capacities were assessed. Baseline results suggested an increased prevalence of malaria parasites in children co-inf...

UNLABELLED The malaria parasite Plasmodium falciparum contains a nonphotosynthetic plastid organelle that possesses plant-like metabolic pathways. Plants use the plastidial isoprenoid biosynthesis pathway to produce volatile odorants, known as terpenes. In this work, we describe the volatile chemical profile of cultured malaria parasites. Among the identified compounds are several plant-like te...

Protection against a lethal challenge infection of Plasmodium falciparum was elicited in malaria-naive Aotus vociferans monkeys by vaccination with the C terminus 19-kDa protein of the major merozoite surface protein (MSP-1(19)) fused to tetanus toxoid universal T-cell epitopes P30 and P2. Three of four monkeys were protected against a 10(4)-parasite challenge. Four monkeys were challenged with...

Malaria parasites invade host cells using actin-based motility, a process requiring parasite actin filament nucleation and polymerization. Malaria and other apicomplexan parasites lack Arp2/3 complex, an actin nucleator widely conserved across eukaryotes, but do express formins, another type of actin nucleator. Here, we demonstrate that one of two malaria parasite formins, Plasmodium falciparum...

OBJECTIVE To study the effects of zinc supplementation on malaria and other causes of morbidity in young children living in an area holoendemic for malaria in west Africa. DESIGN Randomised, double blind, placebo controlled efficacy trial. SETTING 18 villages in rural northwestern Burkina Faso. PARTICIPANTS 709 children were enrolled; 685 completed the trial. INTERVENTION Supplementatio...

Background Malaria is one of tropical and semi-tropical and vector-borne parasitic diseases produced by the protozoan parasites of the genus and species Plasmodium. The aim of this study was to assess the epidemiology and the factors associated with the malaria in children in Sistan and Baluchistan province in 2013-2016. Materials and Methods This cross-sectional study was conducted between Mar...

A broadly effective malaria vaccine is a missing component of the practical tools needed to control and eventually eliminate malaria. For more than 50 years malaria researchers have been searching for a strategy that provides long lasting protection against a broad range of parasite strains. Many different approaches have been tested including whole parasite and subunit vaccines composed of one...

The main impetus for trying to understand immunity to malaria is the need to develop effective malaria vaccines. Despite years of knowing that humans can be immune to malaria the mechanisms underlying this immunity are yet to be properly understood. This is, in part, attributable to the complexity of the malaria parasite and its life cycle resulting in a complex parasite-host relation. The outc...

BACKGROUND The interaction between malaria and under-nutrition is not well elucidated in Ethiopia. The objective of this study was to assess the magnitude of under-nutrition and its correlation with malaria among under-five children in south-west Ethiopia. METHODS This cross-sectional study was undertaken during March-February, 2009 as part of the baseline assessment of a cluster randomized t...

Since 2005, the State of Acre, western Amazon, Brazil, has reported the highest annual parasite incidence (API) of malaria among the Brazilian states. This study examines malaria incidence in Acre using spatial and spatio-temporal analysis based on an ecological time series study analyzing malaria cases and deaths for the time period 1992- 2014 and using secondary data. API indexes were calcula...