the present study was aimed to evaluate the therapeutic potential of pimpinella tirupatiensis (pt) by assaying the activities of selective mitochondrial enzymes in streptozotocin induced diabetic rats. diabetic rats showed a significant (p < 0.01) reduction in the activities of oxidative enzymes succinate dehydrogenase (sdh), malate dehydrogenase (mdh), glutamate dehydrogenase (gdh) and isocitr...

The effect of anti-follicular stimulating hormone (FSH) on testicular lipid and the specific activity of testicular enzymes of the isocitrate dehydrogenase (ICDH), pyruvate/malate dehydrogenase (MDH) and malic enzyme involved in lipogenesis were studied in mature bonnet monkeys, Macaca radiata. Immunization of monkey with anti-FSH for 24 days did not produce any significant changes in the body ...

Reduced nicotinamide-adenine dinucleotide phosphate (NADPH), required as co-factor for lipogenesis and steroidogenesis, may, in part, be supplied by pyridine nucleotide transhydrogenation mediated by malate dehydrogenase (oxaloacetate+NADH\ar=r\malate+NAD) and the malate (`malic') enzyme (malate+NADP\ar=r\pyruvate+CO2 +NADPH). The malate transhydrogenation reactions (cf. Ballard & Hanson, 1967,...

The mechanisms and the controlling factors of malate oxidation by mitochondria from leaves of Kalanchoë blossfeldiana Poelln. plants performing Crassulacean acid metabolism were investigated using Percollpurified mitochondria. The effects of pH and of various cofactors (ATP, NAD(+), coenzyme A) on malate dehydrogenase (EC 1.1.1.37) and malic enzyme (EC 1.1.1.39) solubilized from these mitochond...

Many strict aerobes have a particulate (non-NAD-linked) malate dehydrogenase (Jurtshuk et al., 1969), whereas many facultative anaerobes have only a soluble (NADlinked) malate dehydrogenase. Moraxella fwofi, like Micrococcus fysodeikticus (Cohn, 1958) and Acetobacter xylinium (Benziman & Galanter, 1964), has both a particulate and a soluble dehydrogenase (Jones, 1969; Jones & King, 1972). In th...

Backcross hybrids produced from the bluegill, the red-ear sunfish, and their F(1) interspecific hybrid have been analyzed for the inheritance of six enzyme phenotypes. Malate dehydrogenase A and B, tetrazolium oxidase, 6-phosphogluconate dehydrogenase, skeletal muscle esterase, and liver alpha-glycerophosphate dehydrogenase are all inherited in a mendelian manner as codominant alleles at nuclea...

the effect of anti-follicular stimulating hormone (fsh) on testicular lipid and the specific activity of testicular enzymes of the isocitrate dehydrogenase (icdh), pyruvate/malate dehydrogenase (mdh) and malic enzyme involved in lipogenesis were studied in mature bonnet monkeys, macaca radiata. immunization of monkey with anti-fsh for 24 days did not produce any significant changes in the body ...

Mitochondrial malate dehydrogenase [L-malate, nicotinamide adenine dinucleotide oxidoreductase (EC 1.1.1.37)] from Morris rat hepatomas grown in vivo and from Morris rat hepatoma 7288C grown in cell culture (hepatic tumor cells) has been maximally purified for comparison with mitochondrial malate dehydrogenase from normal rat liver. A rabbit antiserum directed against normal rat liver mitochond...

Respiration utilizing NAD-linked substrates in mitochondria isolated from cotyledons of etiolated peas (Pisum sativum L. var. Homesteader) by sucrose density gradient centrifugation exhibited resistance to rotenone. The inhibited rate of alpha-ketoglutarate oxidation was equivalent to the recovered rate of malate oxidation. (The recovered rate is the rate following the transient inhibition by r...

In extension of a previous study with yeast glucose-6-P dehydrogenase (Kawaguchi, A., and Bloch, K. (1974) J. Biol. Chem. 249, 5793-5800), the structural changes accompanying the inhibition of glutamate dehydrogenase and several malate dehydrogenases by palmitoyl-CoA and by sodium dodecyl sulfate have been investigated. Palmitoyl-CoA converts liver glutamate dehydrogenase to enzymatically inact...