background: the present study was designed to evaluate the survival and proliferation of spermatogonial stem cells from cryptorchid mouse testis in co-culture system over a 3 weeks period. materials and methods: sertoli and spermatogonial cells were isolated from bilateral cryptorchid mouse model testes. isolated spermatogonial cells were co-cultured with sertoli cells in minimal essential medi...

Abstract Background The liver is one of the vital organs involved in detoxification and metabolism. sex-based differences between functionality male female have been previously reported, i.e., male’s are good alcohol clearance lipid metabolism, while female’s better cholesterol To date, studies on novel drug toxicity not considered sex-specific dimorphic nature liver. However, use hepatocyte-li...

Figure Legend: Figure 1 Glycogen accumulation–normal accumulation in hepatocytes in a female B6C3F1 mouse from a chronic study. Figure 2 Glycogen accumulation–normal mobilization of glycogen from centrilobular area in a male B6C3F1 mouse from a subchronic study. Figure 3 Glycogen accumulation–glycogen in all hepatocytes in a male B6C3F1 mouse from a subchronic study. Figure 4 Glycogen depletion...

Background: Fertilization is a multistep process requiring spermatozoa with unique cellular structures and numerous germ cell-specific molecules that function in the various steps. In the highly coordinated process of male germ cell development, RNA splicing and polyadenylation help regulate gene expression to ensure formation of functional spermatozoa. Male germ cells express tauCstF-64 (Cstf2...